Best Life Sciences Companies in Minnesota, United States
The 392 best Life Sciences companies in Minnesota, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Saluda Medical.
Our analysis of 164 Life Sciences companies
$34.7b in tracked funding; 83% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Life Sciences companies in Minnesota
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Saluda Medical Developer of neuromodulation platform measuring biomarkers for chronic neurological condition treatment 62Funding top 14%Moat top 31%News top 39%Growth top 42% All 8 signals ▾Fundingtop 14% Moattop 31% Newstop 39% Growthtop 42% Markettop 44% Techtop 45% Talentbottom 49% Globalbottom 43% Funding: Raised $400M across 8 rounds · 8 rounds over 14 yrs (0.6/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 62/100 | $400M | 7 mo ago | Public | 327 | Jim Schuermann CEO | — | 1 launch |
| 2 | CVRx Developer of implantable technology for hypertension and heart failure | $394M | 71 mo ago | Public | 142 142 → 252 (+77%) | — | 284 patents Implantable baroreflex activation devices and minimally invasive electrode delivery systems | 1 partnership |
| 3 | IDRx Developer of precision combination therapies for cancer | $242M | 22 mo ago | Acquired | 19 | Nicholas Lydon Co-Founder | 5 patents Combination cancer therapeutics using KIT inhibitor regimens | — |
| 4 | Nuvaira Provider of a catheter-based system for patients suffering from COPD 57Funding top 18%Moat top 23%Product top 31%Patents top 33% All 11 signals ▾Fundingtop 18% Moattop 23% Producttop 31% Patentstop 33% Innovationtop 35% Growthtop 40% Talentbottom 49% Marketbottom 46% Techbottom 46% Globalbottom 40% Newsbottom 27% Funding: Raised $191M across 10 rounds · 10 rounds over 17 yrs (0.6/yr) Moat: Editorial + unicorn rating 8/10 · IP moat: 97 patents rank vs industry peers · Fliar Intelligence Index 57/100 | $191M | 3 mo ago | Series E | 57 | Dennis Wahr CEO | 97 patents Minimally invasive therapeutic devices for respiratory, esophageal and catheter-based interventions | 1 job opening |
| 5 | Monteris Minimally invasive robotic laser thermotherapy 55Funding top 15%Moat top 31%Talent top 38%Market top 43% All 8 signals ▾Fundingtop 15% Moattop 31% Talenttop 38% Markettop 43% Growthtop 48% Newsbottom 42% Techbottom 38% Globalbottom 37% Funding: Raised $174M across 20 rounds · 20 rounds over 18 yrs (1.1/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 55/100 | $174M | 3 mo ago | Series E | 100 100 → 128 (+28%) | Richard Tyc Co-Founder & SVP Science & Technology | — | — |
| 6 | Endogenex Developer of medical devices for the treatment of Type 2 diabetes 37Funding top 18%Innovation top 39%Moat top 39%Patents top 41% All 9 signals ▾Fundingtop 18% Innovationtop 39% Moattop 39% Patentstop 41% Talentbottom 49% Globalbottom 37% Techbottom 35% Marketbottom 31% Newsbottom 20% Funding: Raised $140M across 7 rounds · 7 rounds over 8 yrs (0.9/yr) Innovation: 25 patents (top 67% of patent-holders) · 24 filings since 2022 vs 1 in 2017-21 rank vs industry peers · Fliar Intelligence Index 37/100 | $140M | 2 mo ago | Series C | 15 15 → 27 (+80%) | Michael Brenzel Co-Founder & CTO | 25 patents Pulsed electric field electroporation devices for tissue ablation, especially gastrointestinal applications. | 1 launch |
| 7 | Anteristech Provider of technologies for developing heart valve | $126M | 7 mo ago | Public | 27 | — | — | — |
| 8 | Flywheel Cloud based data research platform 80Funding top 14%AI top 20%Product top 21%Moat top 31% All 10 signals ▾Fundingtop 14% AItop 20% Producttop 21% Moattop 31% Innovationtop 32% Techtop 33% Growthtop 35% Talenttop 38% Marketbottom 49% Globalbottom 39% Funding: Raised $110M across 10 rounds · 10 rounds over 8 yrs (1.2/yr) AI: Classified as an AI company rank vs industry peers · Fliar Intelligence Index 80/100 | $110M | 5 mo ago | Series D | 160 | Gunnar Schaefer Co-Founder | — | 1 partnership |
| 9 | Neochord Provider of minimally -invasive devise for valve repair | $108M | 15 mo ago | Series E | 7 | David Chung President & CEO | 142 patents Minimally invasive cardiac valve repair devices and suture anchoring technologies | — |
| 10 | ShiraTronics Developer of a neuromodulating device for treating migraine | $108M | 21 mo ago | Series B | 29 | — | 67 patents Implantable neurostimulation devices for headache relief with wireless charging and communication | — |
| 11 | Vyriad Developer of oncolytic-virus-based immunotherapies for cancer treatment 50Patents top 20%Funding top 21%Innovation top 25%Moat top 32% All 7 signals ▾Patentstop 20% Fundingtop 21% Innovationtop 25% Moattop 32% Techbottom 43% Globalbottom 37% Marketbottom 36% Patents: 70 patents matched (strict assignee match) · 56 filings since 2022 vs 14 in 2017-21 Funding: Raised $100M across 8 rounds · 8 rounds over 8 yrs (1.0/yr) rank vs industry peers · Fliar Intelligence Index 50/100 | $100M | 5 mo ago | Series B | 37 | — | 70 patents Engineered rhabdoviral vectors for cancer immunotherapy and viral antibody diagnostics | — |
| 12 | Sonex Health Innovating ultrasound-guided solutions to transform patient experience, improve safety, lower costs | $90M | 33 mo ago | Series B | 32 | Jay Smith Co-Founder & CMO | — | — |
| 13 | 4C Medical Developer of medical devices for the treatment of mitral regurgitation | $88M | 15 mo ago | Series D | 28 | Jeffrey Chambers Founder | 547 patents Minimally invasive electrosurgical instruments and RF‑activated surgical systems for laparoscopy | — |
| 14 | Francis Medical Developer of a therapeutic solution to treat prostate, kidney, and bladder cancer | $77M | 18 mo ago | Series C | 29 | — | — | 2 launchs |
| 15 | Recombinetics Developer of gene repair and gene-editing technology to create animal models 35Moat top 19%Funding top 30%Patents top 32%Product top 36% All 10 signals ▾Moattop 19% Fundingtop 30% Patentstop 32% Producttop 36% Innovationtop 37% Globalbottom 42% Growthbottom 41% Techbottom 36% Marketbottom 33% Newsbottom 22% Moat: Editorial + unicorn rating 8/10 · IP moat: 242 patents Funding: Raised $66.8M across 25 rounds · 25 rounds over 15 yrs (1.7/yr) rank vs industry peers · Fliar Intelligence Index 35/100 | $67M | 14 mo ago | Series A | 29 29 → 17 (-41%) | — | 242 patents Livestock genome engineering via pluripotent stem cells and non-meiotic allele introgression | — |
| 16 | MIVI Neuroscience Developer of catheters for acute ischemic stroke therapy | $66M | 34 mo ago | Series C | 37 | — | 98 patents Neurovascular catheter systems for aspiration, thrombectomy, and embolic protection in cerebral vessels | — |
| 17 | Cytotheryx Developer of human hepatocytes for research and clinical applications 29Moat top 30%Patents top 37%Funding top 38%Innovation top 41% All 7 signals ▾Moattop 30% Patentstop 37% Fundingtop 38% Innovationtop 41% Talentbottom 49% Globalbottom 35% Marketbottom 25% Moat: IP moat: 14 patents · Soonicorn Patents: 14 patents matched (strict assignee match) · 14 filings since 2022 vs 0 in 2017-21 rank vs industry peers · Fliar Intelligence Index 29/100 | $60M | 5 mo ago | Series A | 12 | John Swart Chief Executive Officer | 14 patents Engineered human hepatocyte production, genetic modification, and biliary delivery platforms | — |
| 18 | Aria CV Device for pulmonary hypertension | $44M | 10 mo ago | Series B | 17 | Dan Gladney Chief Executive Officer | 59 patents Implantable cardiovascular pressure-regulating devices for pulmonary hypertension treatment | — |
| 19 | Predictive Oncology AI-based cancer diagnostic and precision medicines platform 42Funding top 31%Tech top 41%AI top 45%Moat top 48% All 10 signals ▾Fundingtop 31% Techtop 41% AItop 45% Moattop 48% Fin. healthbottom 49% Talentbottom 49% Newsbottom 41% Growthbottom 40% Globalbottom 37% Marketbottom 33% Funding: Raised $43.0M across 9 rounds · 9 rounds over 18 yrs (0.5/yr) Tech: 51 technologies across 3/8 capability areas · Cloud: Akamai, Amazon Web Services rank vs industry peers · Fliar Intelligence Index 42/100 | $43M | 8 mo ago | Acquired | 31 | Carl Schwartz CEO | — | — |
| 20 | KORONIS BIOMEDICAL TECHNOLOGIES Developer of sensors for diagnosis of lung diseases | $40M | 9 mo ago | Funding Raised | — | — | — | — |
| 21 | FOXO Technologies Provider of epigenetic biomarkers discovery and development platform | $40M | 12 mo ago | Public | 15 | — | 3 patents Machine‑learning analysis and quality control of epigenetic DNA data for health diagnostics | — |
| 22 | Cryosa Provider of a therapeutic medical device for treating sleep disorders | $30M | 11 mo ago | Series B | 16 16 → 13 (-19%) | — | 50 patents Cryogenic adipose tissue ablation devices for obstructive sleep apnea treatment | — |
| 23 | iVEAcare Developer of neuromodulation technology intended to treat patients suffering from chronic diseases | $28M | 25 mo ago | Series A | — | Mudit Jain Co-Founder | 5 patents Personalized vagus nerve stimulation and AI-driven seizure/depression monitoring | — |
| 24 | Veravas Provider of platform to manage sample preparation and diagnostic solutions | $25M | 27 mo ago | Series A | 4 | John Forrest Founder and Executive Chairman | 51 patents Multiplex biosensor platforms for detecting and enriching disease biomarkers | 1 award |
| 25 | Reprise Biomedical Developer of surgical mesh for wound management | $23M | 1 mo ago | Series B | 16 | Carrie Powers Chief Executive Officer | — | — |
| 26 | Preceptis Medical Surgical tool for ear tube procedures | $19M | 2 mo ago | Series B | 4 | — | — | — |
| 27 | PamGene Provider of a microarray platform and gene expression profiling system for post-genomic applications | $18M | 35 mo ago | Series B | 38 | — | — | 1 partnership |
| 28 | Vascudyne Developer of regenerative biomaterials for tissue repair and replacement | $18M | 13 mo ago | Series A | 6 | Jeff Franco Co-Founder | 40 patents Engineered tissue implants for cardiovascular valves, grafts, and nerve repair | 1 award |
| 29 | Alpheus Medical Developer of Sonodynamic therapy device for brain cancer | $16M | 13 mo ago | Series B | 7 | Vijay Agarwal Founder & CEO | — | — |
| 30 | Cardio Flow Developer of orbital atherectomy platform for treating calcified and fibrotic plaque | $16M | 24 mo ago | Series A | 2 | Michael Kallok President and CEO | 170 patents Coronary rotational atherectomy and intravascular lithotripsy devices for plaque removal | — |
| 31 | Celcuity Developer of targeted therapies for cancer patients | $15M | 32 mo ago | Public | 42 | — | 74 patents Predictive biomarker assays and companion diagnostics for PI3K/mTOR cancer therapies | — |
| 32 | Humanetics Corporation Clinical-stage biopharma company developing radiation modulators as therapeutics for solid cancers | $13M | 31 mo ago | Funding Raised | 4 | Ronald Zenk Chief Executive Officer and member of the Board of Directors | 99 patents Pharmaceutical genistein formulations for inflammatory/respiratory disorders and radiation sensitizers. | — |
| 33 | Piraeus Medical Developer of solutions for stroke thrombectomy procedures | $11M | 2 mo ago | Series B | — | Jared Hutar Chief Executive Officer | — | — |
| 34 | ABM Respiratory Care Developer of devices for ventilation and airway clearance 45Growth top 35%Moat top 38%Funding top 40%Product top 40% All 9 signals ▾Growthtop 35% Moattop 38% Fundingtop 40% Producttop 40% Techtop 47% Talentbottom 49% Marketbottom 39% Globalbottom 37% Newsbottom 18% Growth: Fresh capital in last 24 mo Moat: Editorial + unicorn rating 5/10 · 1 curated direct competitors tracked rank vs industry peers · Fliar Intelligence Index 45/100 | $10M | 11 mo ago | Series B | 54 | Vinay Joshi CTO and Founder | — | — |
| 35 | AdvancedCPR Solutions Improving CPR outcomes through innovative patient positioning solutions and training | $10M | 16 mo ago | Series A | 10 | Phil Faris Co-Founder & CEO | — | — |
| 36 | MarPam Pharma Provider of chimeric antigen receptor (CAR) based therapeutics solution for treating HIV | $9M | 14 mo ago | Funding Raised | 5 | — | — | — |
| 37 | InSitu Biologics Developer of multi-phase prolonged release drug delivery platform for localized treatments | $8M | 7 mo ago | Series A | 7 | Bill Taylor Co-Founder & Chief Science Officer | 29 patents Patents concentrated in health & consumer products | — |
| 38 | Eden Medical Developer of medical device for the treatment of wounds | $8M | 21 mo ago | Funding Raised | — | Jeffrey Schoess President and CEO | — | — |
| 39 | Phenomix Sciences Provider of test for personalized management of obesity | $8M | 5 mo ago | Series A | 9 | Michael Camilleri Co-Founder | — | — |
| 40 | Minnesota Medical Technologies Provider of medical technology services for people suffering from incontinence | $7M | 6 mo ago | Series A | 15 | David Jonas CEO | — | — |
| 41 | Aplos Medical Developer of an implant to treat acid reflux disease | $5M | 9 mo ago | Funding Raised | — | Claude Tihon Founder & CEO | — | — |
| 42 | Minnesota Medical Technologies Manufacturer of continence care products | $5M | 19 mo ago | Series A | — | Anthony Conway Co-Founder & President | — | — |
| 43 | Luminary Developer of cell therapies for treating cancer | $3M | 8 mo ago | Series B | 8 | — | 6 patents Patents concentrated in health & consumer products | — |
| 44 | EmpNia Developer of precision imaging and radiation therapy for the treatment of cancer patients | $3M | 6 mo ago | Series B | — | Manojeet Bhattacharya Founder & CEO-EmpNia | University of Notre Dame PhD 1998 | 26 patents Real-time respiratory motion monitoring and gating for medical imaging and therapy | — |
| 45 | Be The Match Provider of cell therapy research, patient support, and donor registry | $3M | 10 mo ago | Funding Raised | 2,281 | — | 126 patents AI-driven social networking recommendation and remote conversation facilitation platforms | — |
| 46 | Agitated Solutions Developer of treatment for hypoxemic respiratory failure | $3M | 10 mo ago | Series A | — | Morgan Clyburn Co-Founder & CEO | 30 patents Microbubble contrast agents and ultrasound‑guided imaging/therapy devices for cardiac and musculoskeletal diagnostics. | — |
| 47 | Neuroglide Developer of automated lymphatic drainage therapy for pain relief and lymphatic health | $852K | 13 mo ago | Seed | — | Irene Waldridge Founder & CEO & CTO | — | — |
| 48 | Nascent Surgical Smoke evacuation solutions for cleaner operating rooms and improved patient outcomes | $583K | 14 mo ago | Series A | 3 | Leonard Schultz Founder | 23 patents Surgical smoke and aerosol evacuation systems for operating rooms | — |
| 49 | AcQumen Medical Developer of hemodynamic monitor providing continuous cardiac output for pediatric patients | $341K | 7 mo ago | Seed | — | Rodney Houfburg Co-Founder & CTO | — | 1 award |
| 50 | Niche Biopharmaceuticals Developer of novel anti-infective and anti-inflammatory therapeutics | $300K | 1 mo ago | Seed | — | Dayton Reardan Founder & CEO | 9 patents Sulfur‑based glycerol monoester compounds for antimicrobial and antiviral therapeutics | — |
Top 12 Life Sciences companies in Minnesota
#1
Series E · Plymouth, Minnesota · founded 1999 · 100 employees$174.3Mraised▾
Monteris Medical is focused on providing innovative MRI-guided neurosurgical ablation tools and solutions for neurosurgeons. By combining the imaging power of Magnetic Resonance Imaging (MRI), advanced navigation software and Laser Interstitial Thermal Therapy (LITT), Monteris Medical has created a system to reach virtually any area of the brain.
- Mar 2026Series E$28M
- Mar 2026Conventional Debt$35M
- Oct 2022Conventional Debt$38M
- Oct 2022Series D$35M
#2
Series C · Plymouth, Minnesota · founded 2017 · 15 employees$140.4Mraised▾
Developer of medical devices for the treatment of Type 2 diabetes. The company has developed a novel therapy that utilizes pulsed electric fields to promote regeneration of the duodenal mucosa for improvement in glycemic control in patients with Type 2 diabetes.
- Mar 2026Series C$50M
- Jun 2024Series C$88M
- Oct 2023Series B$18.3M
- Feb 2023Series A$9.2M
#3
Series E · Minneapolis, Minnesota · founded 2008 · 57 employees$191.1Mraised▾
Provider of a catheter-based system for patients suffering from COPD. The company is developing Nuvaira Lung Denervation System, a catheter-based system used to treat the overactive airway nerves in a procedure called Targeted Lung Denervation (TLD). It provides an ablative therapy that opens obstructed airways to improve breathing.
- Feb 2026Series E$35.8M
- Nov 2023Series E$15.1M
- Jan 2022Series E$31.3M
- Feb 2019Series E$79M
#4
Public · Bloomington, Minnesota · founded 2010 · 327 employees$400Mraised▾
Developer of neuromodulation platform measuring biomarkers for chronic neurological condition treatment. It offers a system that measures and records neural activation characteristics. The system quantifies stimulation levels to a clinician-defined target, continuously comparing neural activation with the target level. It automatically adjusts stimulation current to ensure consistent neural activation. The company focuses on neuromodulation solutions for chronic pain. It utilizes Evoked Compound Action Potentials to advance neuromodulation therapy.
- Oct 2025Series F$30M
- Jan 2025Series F$100M
- Apr 2023Series F$150M
- Mar 2022Series F$125M
#5
Series D · Minneapolis, Minnesota · founded 2015 · 160 employees$110Mraised▾
Cloud based data research platform. It is a data research platform provider for the healthcare industry. It provides a platform for data capture, analysis, and research sharing. It also provides a platform for researchers to help in data capture, analysis, and research sharing. It allows data migration for importing data into its systems and combining data from multiple data sets.
- Dec 2025Series D$27.5M
- Oct 2025Series D$2.3M
- May 2025Grant (prize money)$8.7M
- Dec 2024Series D$20M
#6
Series B · Rochester, Minnesota · founded 2016 · 37 employees$100Mraised▾
Developer of oncolytic-virus-based immunotherapies for cancer treatment. The company focuses on the development of new oncolytic virus treatments that leverage Vyriad’s vesicular stomatitis virus (VSV) platform, as well as antibody discovery capabilities. The company's lead product is Voyager-V1 which addresses multiple cancer types.
- Dec 2025Series B$25M
- May 2022Series B$29.5M
- Oct 2019Series A$24.4M
- Sep 2018Grant (prize money)$2.1M
#7
Series B · Plymouth, Minnesota · founded 2019 · 16 employees$23.1Mraised▾
Developer of surgical mesh for wound management. The products developed are FDA-approved MIRODERM (derived from the porcine liver) and MIROMESH (non-crosslinked acellular surgical mesh) that uses perfusion decellularization technology. It is used to treat wounds, ulcers, venous ulcers, chronic vascular ulcers, diabetic ulcers, tunneled and undermined wounds, trauma wounds, drainage wounds, and surgical wounds.
- Jun 2025Series B$6.4M
- Jan 2023Series B$15.3M
- Mar 2021Series A$5M
- Nov 2020Seed$2.8M
#8
Public · Eagan, Minnesota · founded 2006 · 27 employees$126.2Mraised▾
Provider of technologies for developing heart valve. The company has developed a 3D single-piece aortic valve called the DurAVR heart valve that uses its patented ADAPT technology. The other products developed are DurAVR leaflet repair (RP), DurAVR transcatheter heart valve (THV), DurAVR surgical heart valve (SHV).
- Oct 2025Post IPO$11.5M
- Apr 2024Post IPO$15.2M
- Mar 2022Post IPO$20M
- Oct 2021Post IPO$3.8M
#9
Series B · Minneapolis, Minnesota · founded 2011 · 4 employees$19.2Mraised▾
Preceptis Medical is a medical device manufacturer developing surgical tools that allow ear tube procedures to be performed with reduced pain and surgical time for the pediatric patient. Its product, The HUMMINGBIRD TTS Tympanostomy Tube System, gives physicians the option to perform the procedure using moderate or conscious sedation. The device is not commercially available. Participated with Mayo Clinic and Children’s Hospitals and Clinics of Minnesota clinical study.
- Apr 2026Series B$2.6M
- Dec 2020Series B$3.2M
- Mar 2020Series B$3.7M
- Jun 2018Series B$6M
#10
Series A · Rochester, Minnesota · founded 2018 · 12 employees$60Mraised▾
Developer of human hepatocytes (HHC) for research and clinical applications. The company develops HHC for toxicology study, hepatitis research, and allotransplants.
- Jan 2026Conventional Debt—
- Jan 2026Series A$60M
#11
Series B · Maple Grove, Minnesota · founded 2021$11Mraised▾
Developer of solutions for stroke thrombectomy procedures. It offers Wrist-to-Brain thrombectomy system that combines an introducer sheath, guide catheter, and distal access catheter into one device to improve the care of patients suffering from Acute Ischemic Stroke.
- Mar 2026Series B$3.6M
- Oct 2025Series A$662.6K
- Sep 2025Series A$300K
- Feb 2025Series A$2M
#12
Acquired · Eagan, Minnesota · founded 2002 · 31 employees$43Mraised▾
AI-based cancer diagnostic and precision medicines platform. The company has developed an AI-based assessment and inventory for precision medicine and treatment planning. The system uses Multi-omics models analysis and diagnostic technology for decision making.
- Oct 2025Post IPO$50.8M
- Aug 2025Post IPO$413.1K
- May 2022Post IPO$2.3M
- Mar 2021Post IPO$34.4M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Life Sciences coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Biotechnology in Minnesota is moving
A read on the academic research around Biotechnology in Minnesota — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 82 papers.
University of Minnesota leads Minnesota's biotechnology research, focusing on immune cell function, CRISPR, and CAR-T therapy, with a cautiously optimistic tone (mean stance 0.48) skewing toward breakthroughs.
- University of Minnesota66
- University of Minnesota Medical Center12
- University of Minnesota System8
- Minnesota State Community and Technical College2
- Minnesota Department of Health2
- Messenger RNA1→3
- Gene2→4
- Fermentation3
- Microbiome2
- Beekeeping2
- Food additive2
- Characterization (materials science)2
- Transmission (telecommunications)2
- Agriculture2
- Computational biology2
- Genetics2
- Public health1