Best HealthTech Companies in Missouri, United States
The 220 best HealthTech companies in Missouri, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Express Scripts.
Our analysis of 305 HealthTech companies
$32.1b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best HealthTech companies in Missouri
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Express Scripts SaaS-based pharmacy benefit management solutions | $258M | 324 mo ago | 16,291 | — | Cart FunctionalityDrupalApple iCloud Mail+34 | Top 50k | 800 patents Pharmacy data integration, inventory management, and real-time analytics for prescription fulfillment | — |
| 2 | Lumeris AI-powered solutions for value-based primary care transformation | $241M | 26 mo ago | 1,375 1,375 → 1,141 (-17%) | Michael Long Co-CEO | WordPressMySQLPHP+29 | Top 5M | 2 patents Data validation and integrity checking for enterprise data processing | — |
| 3 | Holistic Industries Developer of medical cannabis products | $155M | 44 mo ago | 950 | Josh Genderson Founder & CEO | WordPressApple iCloud MailMicrosoft 365+19 | Top 5M | 15 patents Consumer vaporization and water filtration devices for aromatic and therapeutic applications | — |
| 4 | Benefitfocus Cloud-based platform for benefits administration | $155M | 72 mo ago | 1,094 1,094 → 915 (-16%) | Matt Levin CEO | DrupalApple iCloud MailMicrosoft 365+24 | Top 1M | — | 1 launch |
| 5 | Aratana Therapeutics Developer of small molecules and biologics for the various diseases of companion animals | $77M | 126 mo ago | 83 | Steven Peter Founder | — | — | 128 patents Veterinary NSAID formulations, especially grapiprant oral and ocular delivery systems | — |
| 6 | Paytient Healthcare prepaid cards for employers 69Customers top 22%Funding top 29%Moat top 31%Growth top 32% All 10 signals ▾Customerstop 22% Fundingtop 29% Moattop 31% Growthtop 32% Techtop 36% Talenttop 38% Producttop 46% Marketbottom 49% Globalbottom 44% Newsbottom 21% Customers: Play-Store rating 4.76★ across 1,386 ratings (1 apps) · Review volume +51% in 6 mo Funding: Raised $55.5M across 4 rounds · 4 rounds over 6 yrs (0.7/yr) rank vs industry peers · Fliar Intelligence Index 69/100 | $56M | 12 mo ago | 60 | Daniel Lynn Co-Founder & CTO | WebflowBootstrapGSAP+23 | Top 5M | — | — |
| 7 | Appistry Developer of tools for clinical labs, hospitals to practice genomically enhanced medicine | $44M | 124 mo ago | 16 | Guerry Semones Co-Founder | — | — | 21 patents Distributed, fault‑tolerant middleware for request‑process‑task handling in networked computing | — |
| 8 | SteadyMD Telemedicine platform for concierge primary care | $40M | 37 mo ago | 190 | Guy Friedman Co-Founder & CEO | WordPressMySQLPHP+37 | Top 5M | — | — |
| 9 | Hicuity Health Provider of patient engagement services | $27M | 35 mo ago | 233 233 → 225 (-3%) | Lou Silverman CEO | WordPressMySQLPHP+27 | Top 10M | — | — |
| 10 | BeLeaf Medical Provider of medical cannabis products | $25M | 57 mo ago | 108 108 → 87 (-19%) | Tom Muzzey Co-Founder & CEO | WordPressMySQLPHP+18 | Top 50M | — | — |
| 11 | SentiAR Provider of a 3D visualization platform for interventional cardiac procedures 35Funding top 23%Moat top 25%Talent top 28%Patents top 34% All 9 signals ▾Fundingtop 23% Moattop 25% Talenttop 28% Patentstop 34% Innovationtop 37% Globalbottom 39% Marketbottom 25% Techbottom 22% Newsbottom 22% Funding: Raised $23.3M across 11 rounds · 11 rounds over 9 yrs (1.2/yr) Moat: Editorial + unicorn rating 7/10 · IP moat: 55 patents rank vs industry peers · Fliar Intelligence Index 35/100 | $23M | 1 mo ago | 8 | Michael Southworth Co-Founder | — | — | 55 patents AR-enabled intraoperative visualization and control for cardiac electrophysiology procedures | — |
| 12 | Astarte Medical Gut health monitoring informatics platform for preterm infants | $18M | 56 mo ago | 11 | — | WordPress Block EditorWordPressMySQL+10 | Top 50M | — | — |
| 13 | medZERO Company provides health prepaid cards for employees | $14M | 20 mo ago | 13 | Michael Sobek CSO and Co-Founder | — | — | — | — |
| 14 | Quick Study Radiology Digital imaging solutions for radiology | $14M | 232 mo ago | — | Skip Sallee Founder | — | — | — | — |
| 15 | Rezilient Provider of robotic telehealth device and cloud-based software for clinics and patients | $13M | 21 mo ago | 18 | Jeff Gamble Founder & COO | WebflowGSAPLenis+18 | Top 10M | — | 1 job opening · 2 awards |
| 16 | Radiologics Clinical trial software for imaging | $11M | 13 mo ago | 2 | Daniel Marcus Founder & President | — | — | — | — |
| 17 | Lucet Provider of tech-enabled services to support individuals, payers, and providers | $9M | 44 mo ago | 58 | — | WordPressMySQLMariaDB+25 | Top 5M | — | — |
| 18 | Kenzen Developer of a smart patch for health monitoring | $5M | 64 mo ago | 24 | Sonia Sousa Co-Founder | WordPress Block EditorWordPressMySQL+13 | Top 50M | 6 patents Patents concentrated in health & consumer products | — |
| 19 | Sparo App and smart spirometer for detecting lung health | $4M | 95 mo ago | 4 | Abigail Cohen Co-Founder & Co-CEO | — | — | 18 patents Home-based spirometry devices with gamified data collection and automated analysis | — |
| 20 | Foresite Healthcare Patient health monitoring solutions using AI technology | $4M | 60 mo ago | 2 | George Chronis Chief Executive Officer and Chief Technology Officer | — | — | 34 patents AI-driven patient monitoring and bed‑exit detection using sensor and optical technologies | — |
| 21 | Intuitive Medical Software EHR platform for Urology practices | $3M | 224 mo ago | — | Howard W Follis Founder & Chief Medical Officer | Windows ServerMicrosoft ASP.NETIIS+1 | Top 1M | — | — |
| 22 | Gateway EDI Medical claims processing solutions for health care providers | $3M | 205 mo ago | 300 | — | — | — | — | — |
| 23 | VedaPointe Digital data exchange and business intelligence platform for healthcare providers | $3M | 23 mo ago | 27 | Glen Schuster CEO | — | — | — | 1 partnership |
| 24 | Genetica Developer of a data platform unifying retail data for business insights | $2M | 30 mo ago | 17 | Ben York Chief Executive Officer | — | — | — | — |
| 25 | MedAware Solutions Platform enhances clinical collaboration by exchanging real-time information within secure, patient-centric… | $2M | 122 mo ago | 14 | — | — | — | — | — |
| 26 | Healthy Bytes Fitness and wellness center | $2M | 70 mo ago | 21 | Amy Roberts Founder & CEO | — | — | — | — |
| 27 | NeuroLutions Developer of robotic glove controlled by brain | $2M | 16 mo ago | 9 | Eric Leuthardt Co-Founder | WordPressApple iCloud MailGoogle Workspace+27 | Top 5M | 70 patents BCI-driven neurorehabilitation and assistive orthotic devices for motor control and pain relief | — |
| 28 | Cerner Online platform for employee health benefits | $2M | 80 mo ago | 5,159 | ken Scribner Vice President | Atlassian ConfluenceApple iCloud MailMicrosoft 365+11 | Top 500k | 6 patents Predictive clinical decision support using genetics and cardiac risk analytics | — |
| 29 | Blue Strata Healthcare technology company providing software and services for care continuum | $2M | 130 mo ago | 11 | — | — | — | — | — |
| 30 | StratFit Provider of an online fitness training platform | $2M | 97 mo ago | 1 | — | — | — | — | — |
| 31 | Barnes-Jewish Hospital Online platform to find information and book appointments with the doctors | $1M | 24 mo ago | 7,316 | — | DNNMicrosoft ASP.NETBootstrap+17 | Top 1M | 80 patents Targeted molecular imaging agents and therapeutics for cardiovascular and musculoskeletal diseases | — |
| 32 | PatientsVoices AI-based platform for analyzing patient feedback | $1M | 93 mo ago | 10 | Mary Kay OConnor Founder & CEO | — | — | — | — |
| 33 | Innervo Technology Intraoral device for improving posture | $1M | 80 mo ago | 4 | — | — | — | 4 patents Palatal stimulation devices for intra‑oral balance therapy | — |
| 34 | FIRMM Provider of software to measure data quality for MRI | $1M | 78 mo ago | 5 | Nico Dosenbach Co-Founder | — | — | — | — |
| 35 | HIPAAtrek HIPAA compliance software simplifying policy management, training, and breach risk assessment | $975K | 95 mo ago | 14 | Sarah Badahman Co-Founder | WordPress Block EditorElementorDivi+31 | Top 50M | — | — |
| 36 | iDocsWeb Telehealth solution for long-term care, skilled nursing facilities, and assisted living | $840K | 94 mo ago | 4 | — | — | — | — | — |
| 37 | EDIS Drug data integration platform for pharmaceutical strategy development | $504K | 123 mo ago | 6 | Dan Bemus Co-Founder & Board Member | — | — | — | — |
| 38 | TrackMy Solutions Digital vaccination management tool for providers and employees | $395K | 39 mo ago | 24 | Jeremy Elias Founder & CEO | Wix eCommerceWixSentry+17 | Top 10M | — | 1 partnership |
| 39 | Medinexo Telemedicine marketplace platform for providers | $354K | 120 mo ago | 11 | Jorge Toro President & CEO | — | — | — | — |
| 40 | SmartCare Consultant SmartCare is cloud-based technology which uses Sensor Fusion to aggregate data discretely collected through… | $350K | 141 mo ago | 11 | Bryan Jefferson CEO | — | — | — | — |
| 41 | Mediprocity Messaging app focused on healthcare professionals | $333K | 122 mo ago | 10 | Mason Rothert CEO / Co-Founder | Node.jsZohoTailwind CSS+15 | Top 5M | — | 1 partnership · 1 expansion |
| 42 | Drug Design Methodologies Provider of drug design methodologies with a focus on ligand refinement software | $226K | 100 mo ago | — | Chris Ho Owner | — | — | — | — |
| 43 | SanusEO Mobile texting and web services to support population health management | $200K | 119 mo ago | 11 | — | — | — | — | — |
| 44 | nimble Provider of revenue cycle management solutions for surgical clinics | $150K | 199 mo ago | 237 | Nader Samii CEO | WordPress Block EditorCart FunctionalityWooCommerce+35 | Top 5M | 12 patents Digital pharmacy validation and remote subscription management platforms for e‑commerce transactions | 1 job opening |
| 45 | Provider Pool On-demand recruitment platform provider | $100K | 56 mo ago | 4 | — | — | — | — | — |
| 46 | iRheum Provider of software for rheumatoid diagnosis | $100K | 168 mo ago | — | Jarrod Townsend Co-Founder | — | — | — | — |
Top 12 HealthTech companies in Missouri
#1
Series B · St. Louis, Missouri · founded 2017 · 8 employees$23.3Mraised▾
Provider of a 3D visualization platform for interventional cardiac procedures. Using a head-up display, it enables a clinician to see the anatomic model and allows for accurate and safe procedures.
- Apr 2026Series B$1.5M
- Apr 2025Series B$2.5M
- Apr 2023Series B$8.5M
- Apr 2021Series A$5.1M
#2
Series B · Columbia, Missouri · founded 2018 · 60 employees$55.5Mraised▾
Healthcare prepaid cards for employers. It enables employers to offers prepaid cards to employees in order to make payments for healthcare expenses such as medicines, health insurance, medical bills, and more. It offers a dashboard for customized payment plans and payment management. It provides an app-based platform that is available on Android devices.
- Jun 2025Conventional Debt$40M
- Jan 2023Series B$33M
- Jan 2023Venture Debt$7.5M
- Oct 2020Series A$3.9M
#3
Series D · Maryland Heights, Missouri · founded 2001 · 1375 employees$241Mraised▾
AI-powered solutions for value-based primary care transformation. It partners with health systems, physician groups, and payers to improve patient outcomes, reduce costs, and streamline operations through its Tom platform.
- Apr 2024Series D$100M
- Oct 2023Conventional Debt$50M
- Jul 2014PE$71M
- May 2014PE$71M
#4
Acquired · Saint Louis, Missouri · founded 2008 · 2 employees$10.5Mraised▾
Radiologics provides clinical trial software for imaging. XNAT CR, their platform helps in image data management for clinical trials. The platform offers file transfer and verification, integration with clinical data, automation of image processing routines, and connectivity with preferred imaging workstations. It has DICOM features that enable secure storage, verification, query, and retrieval of DICOM data.
- May 2025Grant (prize money)$8.7M
- Sep 2020Grant (prize money)$255.9K
- Sep 2017Grant (prize money)$1.5M
- 2016Grant (prize money)$50K
#5
Seed · Kansas City, Missouri · founded 2017 · 13 employees$14.4Mraised▾
Company provides health prepaid cards for employees. It is a perk provided by the employer that allows employees to acquire loans to pay their medical expenditures. It enables customers to apply for and receive loans entirely online.
- Oct 2024Seed$590K
- Oct 2022Seed$8.7M
- Mar 2021Seed$5.7M
#6
Series A · St. Louis, Missouri · founded 2016 · 18 employees$12.6Mraised▾
Rezilient provides robotic telehealth devices for clinics. The physicians can assume control of a mobile medical robot in the network, allowing them to deliver telehealthcare physically. Through this device, doctors can perform physical assessments through video conferencing.
- Aug 2024Series A$10M
- Aug 2021Seed$2.5M
- Sep 2020Seed$120K
#7
Series B · Maryland Heights, Missouri · founded 2014 · 950 employees$155Mraised▾
Developer of medical cannabis products. The company claims to develop and offer a wide range of proprietary strains that increase desired cannabinoids such as cannabidiol (CBD), with its low psychoactivity and lack of other side effects.
- Oct 2022Series B$5M
- May 2021Series B$55M
- Apr 2021Series B$38M
- Sep 2020Conventional Debt$35M
#8
Series A · St. Louis, Missouri · founded 2007 · 9 employees$2Mraised▾
NeuroLutions is developing devices based on brain-computer interface technology restoring functions in patients disabled due to neurological injury. It is developing a robotic glove that the user can wear it on their hand and a headset.
- Feb 2025Series A$26.5M
- Sep 2022Grant (prize money)$2M
- Jun 2015Seed$1.1M
- Nov 2008Seed$625K
#9
Acquired · St. Louis, Missouri · founded 2016 · 190 employees$39.5Mraised▾
SteadyMD is a telemedicine platform that aims to provide concierge primary care services to users via chat, video, or phone call. The company promises a dedicated doctor who gets to know the patient closely and becomes a personal medical advisor. In addition, the platform stores all the data on consultations and provides a place for users to store information on weight, blood pressure, and other vitals.
- May 2023Series C—
- Mar 2021Series B$28M
- Apr 2020Series A$6M
- Sep 2019Series A$2.6M
#10
Series C · St. Louis, Missouri · founded 2004 · 233 employees$27.4Mraised▾
Provider of patient engagement services
- Jun 2023Series C—
- Mar 2016Series C$11.5M
- Jul 2015Series C$7.3M
- Feb 2014Unattributed$241K
#11
Seed · St. Louis, Missouri · founded 2019 · 27 employees$2.7Mraised▾
Digital data exchange and business intelligence platform for healthcare providers. The company has developed software that enables users to exchange clinical and administrative healthcare data with each other. It has features for customizing platforms, data collection, data access, and more.
- Jul 2024Seed$2.7M
#12
Acquired · Charleston, Missouri · founded 2000 · 1094 employees$154.7Mraised▾
Cloud-based platform for benefits administration. The company's products for insurance carriers include enrollment that provides online enrollment for various benefits, eBilling, an electronic invoice presentation, a payment solution, and an exchange solution that bridges the communication gap between carrier and employer systems. It provides eSales that give carriers and brokers tools to organize and manage accounts, track leads, generate quotes, and create proposals for various products. Its products for insurance carriers also comprise eDirect which enables carriers to sell policies directly to individuals.
- Jun 2020Post IPO$80M
- Mar 2015Post IPO$74.7M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of HealthTech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Missouri is moving
A read on the academic research around Digital Health in Missouri — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 46 papers.
University of Missouri and affiliates lead Missouri's digital-health research, focusing on EHR systems and AI, with a cautiously optimistic tone amid growing concern.
- University of Missouri29
- Missouri State University9
- University of Missouri Health System5
- University of Missouri–Kansas City4
- University of Missouri–St. Louis2
- Key (lock)4
- Health care3
- SNOMED CT3
- Interoperability3
- Unstructured data3
- Health informatics1→5
- Health informatics1→5