Best HealthTech Companies in Chicago, United States
The 434 best HealthTech companies in Chicago, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Tempus.
Our analysis of 305 HealthTech companies
$32.1b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best HealthTech companies in Chicago
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Tempus 🦄 Developer of genomic testing and artificial intelligence tools for medicine | $1.1B | 43 mo ago | Public | 772 | Eric Lefkofsky Founder & CEO | Cart FunctionalityWordPressApple iCloud Mail+33 | 594 patents AI-powered medical diagnostics: imaging biomarkers, liquid biopsy genomics, and cardiac ECG analysis | — |
| 2 | RLDatix GRC software solutions for the healthcare industry | $736M | 53 mo ago | Late Stage | 1,400 | Dan Michelson CEO | WordPressApple iCloud MailMySQL+33 | — | — |
| 3 | Outcome Health 🦄 Online patient engagement tool for providers | $533M | 107 mo ago | Acqui-Hired | 221 | — | — | — | — |
| 4 | Xeris Pharmaceuticals Developer of liquid-stable injectables for the delivery of drugs | $155M | 53 mo ago | Public | 294 294 → 506 (+72%) · sector median +42% | Steve Prestrelski Co-Founder & CSO | DrupalApple iCloud MailPHP+32 | 249 patents Stable drug formulations, especially levothyroxine, using aprotic polar solvents | 1 internship · 1 award |
| 5 | Evozyne Developer of proteins using protein engineering technology | $144M | 33 mo ago | Series B | 73 | Rama Ranganathan Co-Founder & CSO | WordPressMySQLPHP+17 | 2 patents AI-driven design of synthetic proteins for protein engineering applications | — |
| 6 | HealthJoy Web and smart phone based teleconsultation platform | $113M | 43 mo ago | Series D | 141 141 → 285 (+102%) · sector median +42% | Doug Morse-Schindler President & Co-Founder | HubSpot CMS HubApple iCloud MailGoogle Workspace+27 | — | 2 launchs |
| 7 | Pathos 🦄 Provider of AI based drug discovery platform for drug development | $102M | 14 mo ago | Series D | 12 | Ryan Fukushima Co-Founder | DudaApple iCloud MailGoogle Workspace+14 | — | 2 job openings · 1 internship |
| 8 | Fyllo Online marketing platform for cannabis products | $96M | 55 mo ago | Series C | 130 | — | — | — | — |
| 9 | Upfront Healthcare Provider of data analytics platform to help clinics schedule and allocate resources | $96M | 36 mo ago | Acquired | 45 45 → 26 (-42%) · sector median +42% | Carrie Kozlowski COO & Co-Founder | Froala EditorSalesforceMicrosoft ASP.NET+10 | — | — |
| 10 | Higi Gamified app for personal health management | $95M | 71 mo ago | Acquired | 53 53 → 75 (+42%) · sector median +42% | — | Cart FunctionalitySquarespace CommerceSquarespace+25 | 17 patents Automated cuff blood pressure/arm circumference measurement devices and ocular biomolecule detection systems. | 1 partnership |
| 11 | NOCD Mobile app for treating obsessive-compulsive disorder | $85M | 40 mo ago | Series C | 14 | Evan Bogart Founder & CEO | Node.jsHeadless UITailwind CSS+28 | — | — |
| 12 | Cylinder Health Digital health platform offering solutions for individuals with digestive health issues | $78M | 32 mo ago | Series B | — | Bill Snyder Co-Founder & CEO | WordPressApple iCloud MailGoogle Workspace+30 | — | — |
| 13 | Nucle AI AI-assisted platform for image analysis | $60M | 26 mo ago | Series B | 9 | Lotan Chorev Co-Founder and VP R&D | — | — | — |
| 14 | TimeDoc Provider of the chronic care management solution for healthcare professionals | $57M | 50 mo ago | Series B | 156 | William Boeglin Co-Founder & CEO | WordPressMySQLPHP+32 | — | — |
| 15 | Janus AI AI and SaaS-based revenue cycle management tool for healthcare providers | $56M | 20 mo ago | Series B | 94 94 → 110 (+17%) · sector median +42% | Brendan Downing Co-Founder & CEO | — | 28 patents Hardware security and access control solutions for computing devices and network interfaces | 3 job openings · 2 partnerships |
| 16 | Visibly Online vision test technology for providers | $50M | 38 mo ago | Series B | 29 29 → 62 (+114%) · sector median +42% | — | Apple iCloud MailGoogle WorkspaceNode.js+15 | 19 patents Camera‑based ophthalmic diagnostics for refraction, astigmatism, and visual‑field assessment | — |
| 17 | Kalderos Online platform to coordinate and manage drug discount programs | $50M | 17 mo ago | Series C | 110 | James William Schuyler Co-Founder | WebflowSentryZendesk+21 | 2 patents Healthcare marketplace financial transaction platforms for patient payments and secondary trades | 1 partnership |
| 18 | Annexus Health Patient access and patient engagement solutions | $43M | 46 mo ago | Series B | 156 156 → 128 (-18%) · sector median +42% | Brad Frazier Co-Founder | WordPress Site EditorWordPressApple iCloud Mail+28 | — | — |
| 19 | Waltz Health AI-based medical prescription cost management tool for payers and consumers | $35M | 18 mo ago | Acquired | 32 32 → 39 (+22%) · sector median +42% | Jonathon Thierer Co-Founder and Senior Vice President of Product | MUIAzure Front DoorReact+9 | — | — |
| 20 | Blueprint Provider of AI-powered documentation and insights for mental health therapists | $32M | 14 mo ago | Series B | 4 | Danny Freed Founder & CEO | WebflowSentryQuill+33 | — | — |
| 21 | KeyCare Digital teleconsultation tool for providers and patients 45Funding top 25%News top 36%Moat top 39%Growth top 45% All 8 signals ▾Fundingtop 25% Newstop 36% Moattop 39% Growthtop 45% Techtop 45% Talentbottom 49% Marketbottom 40% Globalbottom 37% Funding: Raised $29.5M across 4 rounds · 4 rounds over 4 yrs (1.0/yr) News: 2 BI events in 12 mo (of 4 tracked, 2 types) · Top themes: Funding, Capital raise rank vs industry peers · Fliar Intelligence Index 45/100 | $29M | 3 mo ago | Series A | 21 | Lyle Berkowitz Founder & CEO | WebflowSalesforceHubSpot+18 | — | — |
| 22 | Third Eye Health Provider of virtual care and coordination software for hospitals | $25M | 33 mo ago | Series A | 50 | Lucas Baran Co-Founder & CTO | WordPressApple iCloud MailMicrosoft 365+20 | — | 1 job opening · 1 partnership |
| 23 | CancerIQ Cloud-based platform to doctors, for identifying cancer risk patients and delivering care plans | $24M | 21 mo ago | Series B | 78 | Feyi Olopade CEO | SkolengoSentryZendesk+17 | — | 1 launch |
| 24 | Prenosis AI-based precision diagnostic platform for acute care | $20M | 4 mo ago | Series A | 29 | Rashid Bashir Co-Founder | WordPressApple iCloud MailMicrosoft 365+27 | 21 patents AI-driven clinical risk prediction, dataset normalization, and personalized therapy dashboards | — |
| 25 | Thoughtful AI-powered healthcare administration platform to automate tasks | $20M | 14 mo ago | Series A | 16 | Alex Zekoff Co-Founder & CEO | WebflowZohoYouTube+29 | — | — |
| 26 | Praia Health Provider of a platform as a service technology for patient engagement | $20M | 19 mo ago | Series A | — | Justin Dearborn Founder & CEO | — | — | — |
| 27 | Dina Provider of an AI-based senior care coordination software for healthcare organizations | $18M | 28 mo ago | Acquired | 38 38 → 68 (+79%) · sector median +42% | Ashish Shah Co-Founder & CEO | — | — | — |
| 28 | SimBioSys Provider of AI-based decision-making and cancer diagnosis tool for healthcare professionals | $15M | 17 mo ago | Series A | 46 | Joseph Peterson Founder and CTO | WordPressApple iCloud MailMicrosoft 365+27 | 12 patents Patient-specific 3D tumor modeling and perfusion MRI-based cancer prognostics | — |
| 29 | SonarMD Cloud-based care management solutions for chronic conditions 48Funding top 32%Growth top 35%Talent top 38%Tech top 39% All 7 signals ▾Fundingtop 32% Growthtop 35% Talenttop 38% Techtop 39% Producttop 46% Marketbottom 30% Globalbottom 29% Funding: Raised $14.3M across 5 rounds · 5 rounds over 8 yrs (0.6/yr) Growth: Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 48/100 | $14M | 3 mo ago | Series B | 25 | Lawrence Kosinski Founder at SonarMD | WordPressApple iCloud MailMicrosoft 365+21 | — | — |
| 30 | Cardio Diagnostics AI based platform offering cardiovascular medicine | $14M | 28 mo ago | Public | — | Robert Philibert Co-Founder | WordPress Block EditorCart FunctionalityBuilder.io+19 | — | — |
| 31 | Blueprint Provider of patient assessment tool for behavioural medical practices | $14M | 35 mo ago | Series A | 18 | Danny Freed Founder & CEO | SentryCannyApple iCloud Mail+34 | — | 3 launchs |
| 32 | First Stop Health Online and on-call health concierge | $13M | 35 mo ago | Seed | 1 | Patrick Spain Co-Founder | SentryPythonSalesforce+20 | — | — |
| 33 | ResetSmile Online platform offering a custom tooth replacement device | $10M | 13 mo ago | Series A | — | Clay Teufel Co-Founder | — | — | — |
| 34 | BiomeSense Developer of AI-enabled technology platform for microbiome data generation and analysis | $8M | 15 mo ago | Seed | 5 | Jack Gilbert Co-Founder | WebflowGSAPLenis+11 | 11 patents Microbiome diagnostic tools for stool sample collection and analysis | — |
| 35 | When Insurance Provider of health insurance services for employees | $7M | 6 mo ago | Series A | 8 | — | SentryZendeskApple iCloud Mail+18 | — | — |
| 36 | MetaMe Health Provider of digital therapeutics for gut health | $6M | 26 mo ago | Seed | 8 | — | — | — | — |
| 37 | Adoreal Provider of an aesthetics companion that offers various treatments and procedures | $6M | 20 mo ago | Series A | — | Thomas Fuller Co-Founder & CEO | TypeScriptGoogle MapsZone.js+15 | — | 1 partnership |
| 38 | Hoodie Analytics Provider of market analytics software for cannabis dispensary management | $5M | 23 mo ago | Series A | — | Wes Shepherd CEO | Cart FunctionalityWordPressMySQL+26 | — | 1 launch |
| 39 | Adaptive Testing Technologies Provider of software for mental health assessment for patients | $5M | 16 mo ago | Funding Raised | 5 | David Weiss Founder | — | — | — |
| 40 | TeleTeachers Online platform offering e-learning services 29Funding top 38%Talent bottom 49%Market bottom 42%Global bottom 29% All 4 signals ▾Fundingtop 38% Talentbottom 49% Marketbottom 42% Globalbottom 29% Funding: Raised $4.3M across 3 rounds · 3 rounds over 6 yrs (0.5/yr) Talent: 1 named leader on record · 1 C-suite/founder profile curated rank vs industry peers · Fliar Intelligence Index 29/100 | $4M | 8 mo ago | Series A | 28 | Emily Smith Founder & CEO | — | — | — |
| 41 | Grove Biopharma Developer of AI-based drug modality platform for protein-based drugs | $4M | 13 mo ago | Series A | 7 | Geoff Duyk Co-Founder | WebflowGSAPcore-js+10 | — | — |
| 42 | Beacon Developer of intelligent disinfection technology for air and surfaces | $4M | 13 mo ago | Series A | — | Andrea Clark Founder & Head of Product and Research | Wix eCommerceWixSentry+19 | — | 1 launch |
| 43 | Neopenda Provider of wearable neonatal signs monitor 16Moat top 38%Funding top 42%Tech top 43%Talent bottom 49% All 12 signals ▾Moattop 38% Fundingtop 42% Techtop 43% Talentbottom 49% Productbottom 47% Growthbottom 43% Globalbottom 37% Innovationbottom 36% Patentsbottom 25% Marketbottom 22% Fin. healthbottom 19% Newsbottom 18% Moat: Editorial + unicorn rating 7/10 · IP moat: 3 patents Funding: Raised $2.7M across 12 rounds · 12 rounds over 8 yrs (1.5/yr) rank vs industry peers · Fliar Intelligence Index 16/100 | $3M | 1 mo ago | Seed | 14 | Teresa Cauvel Co-founder and CTO | WixSentryBootstrap+14 | 3 patents Wearable neonatal vital‑sign monitoring systems | 1 job opening · 1 launch · 1 expansion |
| 44 | Planbase Scheduling and workforce management software for healthcare providers | $3M | 7 mo ago | Seed | — | Joe S Co-Founder | — | — | 1 launch |
| 45 | HumanImage Developer of three-dimensional imaging device for skin lesion and cancer tracking | $2M | 2 mo ago | Seed | — | David Teplica Founder & CEO & CMO | — | 5 patents Three‑dimensional body surface imaging for medical and fitness avatar creation | — |
| 46 | Graymatter Labs Online paltform offering nutritional supplemnets to improve health 62Growth top 28%Talent top 38%Tech top 44%Funding bottom 48% All 5 signals ▾Growthtop 28% Talenttop 38% Techtop 44% Fundingbottom 48% Globalbottom 48% Growth: Web rank 5,000,000 → 1,000,000 YoY · Fresh capital in last 24 mo Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 62/100 | $1M | 7 mo ago | Seed | — | Jim Phillips Co-Founder | Cart FunctionalityShopifyEasyGift+38 | — | — |
| 47 | Altris AI-based diagnostic solution for ophthalmologists | $1M | 16 mo ago | Seed | 15 | Andrey Kuropyatnyk Founder & CEO | WordPressMySQLPHP+26 | — | 1 launch |
| 48 | Renalis Provider of solutions for pelvic health | $944K | 20 mo ago | Seed | 3 | Missy Lavender Founder & CEO | — | 4 patents Digital pelvic health education and management platform delivering personalized therapeutic content. | — |
| 49 | Third Coast Dynamics Developer of cloud-based solution delivering hemodynamic assessments from CT and MR angiography images | $657K | 21 mo ago | Funding Raised | — | Bradley Allen Co-Founder | — | — | — |
| 50 | Kompass Diagnostics Provider of a portable fertility monitor for breaking barriers to fertility care | $305K | 13 mo ago | Funding Raised | — | Hyun-June Jang Co-Founder | — | — | — |
Top 12 HealthTech companies in Chicago
#1
Series A · Chicago, Illinois · founded 2020 · 21 employees$29.5Mraised▾
Digital teleconsultation tool for providers and patients. It offers Epic-based virtual care platform which offer virtual care network, patients can book appointments through the MyChart portal or call center.
- Mar 2026Series A$27.4M
- Apr 2025Series A$27.7M
- Jan 2023Series A$27M
- Mar 2022Seed$2.5M
#2
Series A · Chicago, Illinois · founded 2014 · 29 employees$20Mraised▾
AI-based precision diagnostic platform for acute care. It offers Immunix precision diagnostics and evidence generation platform that leverages machine learning algorithms, clinical data, deep biological data, and biobanked sample to identify and treat patient with sepsis.
- Jan 2026Series A$20M
- Sep 2024Grant (prize money)$700K
- Jul 2023Grant (prize money)$4.8M
- Jun 2023Grant (prize money)$4.9M
#3
Series B · Chicago, Illinois · founded 2009 · 25 employees$14.3Mraised▾
Cloud-based care management solutions for chronic conditions. It offers a care coordination program that proactively connects patients with care teams in real time and provides wrap-around services to help patients manage their individual health needs. Their platform collects patient health data through surveys and analyzes it to track the status of improvement. They generate scores from the survey and send alerts to doctors.
- Feb 2026Series B$3M
- Dec 2024Series A$2.2M
- Jul 2024Conventional Debt$1M
- May 2023Series A$4.3M
#4
Seed · Chicago, Illinois · founded 2015 · 14 employees$2.7Mraised▾
Provider of wearable neonatal signs monitor. The device is a small low-cost neonatal vital signs monitor integrated into a baby hat and uses a simple sensor array to measure heart rate, respiratory rate, blood oxygen saturation, and temperature. The sensors are powered by rechargeable batteries, and wirelessly transmit data to a central monitor which alerts attending healthcare professionals when a newborn is in immediate danger. It is intended for critically ill newborns being cared for in hospitals in low-resource countries such as Uganda.
- Apr 2026Conventional Debt$35K
- Nov 2024Conventional Debt$200K
- Sep 2022Conventional Debt$700K
- Apr 2021Seed$1.4M
#5
Pathos 🦄Series D · Chicago, Illinois · founded 2022 · 12 employees$102Mraised▾
Provider of AI based drug discovery platform for drug development. The company licenses or co develops clinical stage therapeutics, optimizing patient selection strategies for accelerated, biomarker driven drug development. It utilizes real world oncology data and patient derived functional genomic data to identify and validate compelling biology, aiming to develop efficacious drugs for patients with unmet needs and enhance patient outcomes.
- Apr 2025Series D$283M
- Oct 2024Series C$62M
#6
Series A · Chicago, Illinois · founded 2020 · 8 employees$7Mraised▾
Provider of health insurance services for employees. It offers health and financial wellness insurance services for individuals and families. Its employees can view their benefit amount and get answers to common health insurance questions on the platform. It provides services to the employees after a job loss with their COBRA continuation plan.
- Dec 2025Series A$10.2M
- Apr 2025Seed$50K
- Jun 2024Seed$4.6M
- 2023Seed$2.4M
#7
Series B · Chicago, Illinois · founded 2019 · 4 employees$31.9Mraised▾
Provider of AI-powered documentation and insights for mental health therapists. It offers AI-assisted progress notes and treatment plans, generating these documents from session recordings. The platform provides real-time clinical assistance before, during, and after client sessions, including reminders, suggestions, and post-session resources. It integrates with existing electronic health record (EHR) systems and prioritizes data security and privacy, adhering to relevant compliance standards. The service aims to streamline workflows and improve the efficiency of mental health practices.
- Apr 2025Series B$15M
- Jun 2023Series A$6.6M
- Jun 2023Series A$9M
- Apr 2019Seed$1.3M
#8
Seed · Chicago, Illinois · founded 2021$1.5Mraised▾
Developer of three-dimensional imaging device for skin lesion and cancer tracking. The company develops AnthroCam, a 3D imaging device that creates high-resolution, life-sized avatars of skin surfaces using non-invasive visible light technology. It enables tracking subtle changes for early skin cancer detection, rooted in decades of anatomic imaging research.
- Mar 2026Seed$1.5M
#9
Series C · Chicago, Illinois · founded 2016 · 110 employees$49.9Mraised▾
Provider of an online platform for managing drug discount programs. The platform tracks and records the validation tests of data and custom validation tests. it also offers features such as compliance issues verification, claims level visibility, transparency in the drug supply chain, and communication for dispute resolution among the affected parties.
- Dec 2024Series C$26.4M
- Sep 2022Series B$14.9M
- Jun 2020Series B$28M
- May 2019Series A$7M
#10
Series A · Chicago, Illinois · founded 2019 · 28 employees$4.3Mraised▾
Online platform offering e-learning services. It is a behavioral health platform offering teletherapy services to schools and organizations serving vulnerable students and youth.
- Oct 2025Series A$1.3M
- Nov 2022Series A$1.5M
- Jul 2020Series A$2.8M
#11
Series A · Chicago, Illinois · founded 2020 · 16 employees$20Mraised▾
AI-powered healthcare administration platform to automate tasks. The company offers solutions for automating revenue cycle management, streamlining company processes, and implementing robotic process automation (RPA).
- Apr 2025PE—
- Jul 2024Series A$20M
#12
Series B · Chicago, Illinois · founded 2020 · 94 employees$56Mraised▾
AI and SaaS-based revenue cycle management tool for healthcare providers. It provides an end-to-end revenue cycle platform to provide operational insights, patient access, collecting data, claims management, navigating payer portals, and more.
- Sep 2024Series B$10M
- Mar 2023Series B$45.1M
- Dec 2021Series A$8.9M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of HealthTech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Chicago is moving
A read on the academic research around Digital Health in Chicago — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 127 papers.
University of Illinois Chicago, University of Chicago, and Loyola University Chicago lead Chicago's digital-health research, focusing on AI, EHR systems, and digital mental health, with a cautiously contested tone (mean stance 0.18).
- University of Illinois Chicago68
- University of Chicago47
- Loyola University Chicago14
- Chicago Department of Public Health12
- Chicago State University2
- Wearable computer3
- SNOMED CT3
- Interoperability3
- Unstructured data3
- Key (lock)3
- Informatics1→5
- mHealth1→4
- Telemedicine1→3
- Data science1→3
- Health informatics2→12
- Health administration1→8