Best HealthTech Companies in Tennessee, United States
The 348 best HealthTech companies in Tennessee, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Main Street.
Our analysis of 305 HealthTech companies
$32.1b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best HealthTech companies in Tennessee
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Main Street 🦄 Value-based healthcare company focused on serving rural areas | $505M | 32 mo ago | Series D | 5 | Bennett Graham Co-Founder | WordPressMySQLPHP+28 | 21 patents Patents concentrated in electrical & electronics | — |
| 2 | SmileDirectClub Developer of customized dental aligners | $440M | 64 mo ago | Deadpooled | 1,360 | Jordan Katzman Co-Founder | — | 132 patents AI-driven 3D imaging and treatment planning for orthodontic tooth movement | — |
| 3 | MedSolutions Medical Cost Management Solutions | $300M | 187 mo ago | Late Stage | 1,000 | Sudhir Shetty Founder And Director | — | — | — |
| 4 | Passport Health Communication Provider of revenue cycle management solution for healthcare organizations | $236M | 214 mo ago | Acquired | 343 | — | — | — | — |
| 5 | Thyme Care 🦄 Provider of home nursing care services | $178M | 14 mo ago | Series D | 123 | Robin Shah Co-Founder & CEO | HubSpot CMS HubApple iCloud MailGoogle Workspace+26 | — | 3 job openings |
| 6 | Digital Reasoning AI-based consumer behavior analysis for banks and financial institutions | $128M | 76 mo ago | Acqui-Hired | 97 | — | — | 57 patents AI-driven risk analytics and compliance monitoring for multilingual financial communications | — |
| 7 | Upperline Health Network of specialty clinics providing podiatry, vascular, and chronic care management | $109M | 16 mo ago | Series C | 1,000 | David Thorpe CEO | WordPress Block EditorWordPressApple iCloud Mail+22 | — | — |
| 8 | Specialty Networks Radiology imaging solution | $95M | 100 mo ago | Series C | 136 | — | — | — | — |
| 9 | MModal Provider of speech based documentation and transcription solution | $81M | 99 mo ago | Acquired | 3,028 | — | — | 192 patents Automated clinical documentation, coding, and workflow tools for medical speech dictation and data reconciliation. | — |
| 10 | XSOLIS AI-based platform for physicians and payers to analyze denial management | $75M | 59 mo ago | Series C | 166 166 → 244 (+47%) | Joan Butters CEO | WordPressSentryApple iCloud Mail+26 | — | — |
| 11 | Echelon Provider of smart indoor exercise bike with live training classes | $65M | 61 mo ago | Series A | 290 | Lou Lentine Founder & CEO | Cart FunctionalityShopifyApple iCloud Mail+18 | 166 patents Powerline communication and smart‑grid networking for meters, lighting, and IoT devices | — |
| 12 | Lirio Provider of an AI-based patient engagement and health management software for payers and doctors 62Funding top 22%AI top 30%Moat top 36%Growth top 40% All 9 signals ▾Fundingtop 22% AItop 30% Moattop 36% Growthtop 40% Techtop 44% Newsbottom 47% Marketbottom 46% Talentbottom 41% Globalbottom 37% Funding: Raised $54.4M across 10 rounds · 10 rounds over 7 yrs (1.4/yr) AI: Classified as an AI company · Product described with: ai-based rank vs industry peers · Fliar Intelligence Index 62/100 | $54M | 1 mo ago | Series C | 94 94 → 113 (+20%) | Michael West Chairman and CEO | WordPressApple iCloud MailMicrosoft 365+33 | — | — |
| 13 | Simplex Healthcare Mail order supplier of diabetic testing supplies for seniors. | $53M | 194 mo ago | Acqui-Hired | 142 | Doug Hudson Founder & CEO | — | — | — |
| 14 | Nuscriptrx On-site dispensing solution for long-term care facilities and their residents | $46M | 135 mo ago | Series C | 42 | Richard J. Wager Founder / President | — | — | — |
| 15 | axialHealthcare Cloud-based risk and pain management tool for healthcare professionals | $45M | 75 mo ago | Series C | 85 | John Donahue CEO | — | — | 2 job openings · 2 awards |
| 16 | Intellivo Provider of claims detection and recovery solution within the healthcare industry | $40M | 46 mo ago | Late Stage | 69 | Laura Hescock Chief Executive Officer | — | — | — |
| 17 | Change Healthcare Cloud-based suite solution for payers, providers and patients | $36M | 81 mo ago | Acquired | 11,310 | — | Adobe Experience ManagerApple iCloud MailJava+23 | 208 patents AI-driven clinical data processing, trial patient identification, and medical imaging rendering solutions | — |
| 18 | I-O Urology Remote patient monitoring system for urology | $35M | 26 mo ago | Series A | — | Britton Garrett CEO | — | — | — |
| 19 | myNEXUS Provider of patient health benefit management and remote monitoring platform for healthcare providers | $32M | 68 mo ago | Acquired | 222 | — | — | — | — |
| 20 | Bluhen Botanicals Producer and supplier of cannabis products | $32M | 84 mo ago | Series A | 30 | — | — | — | — |
| 21 | MDsave Online marketplace for healthcare services | $29M | 89 mo ago | Acquired | 7 | Paul Ketchel CEO | Cart FunctionalityContentfulApple iCloud Mail+37 | 15 patents Online healthcare marketplace platform enabling bundled medical service and product purchases | — |
| 22 | Stratasan Providing SaaS platform for healthcare market intelligence. | $28M | 83 mo ago | Acquired | 87 | — | — | — | — |
| 23 | MindCare Solutions Tele-behavioral health solution for the providers | $28M | 59 mo ago | Series A | 75 75 → 123 (+64%) | Brad Dunbar Chief Executive Officer | WordPressMySQLPHP+23 | — | 1 job opening · 1 partnership |
| 24 | Reimagine Care Provider of in-home cancer care and nursing services | $25M | 7 mo ago | Series A | 23 | — | — | — | 1 job opening · 2 partnerships · 1 expansion |
| 25 | Shareable Ink Cloud-based platform for digitization of clinical documentation | $25M | 132 mo ago | Deadpooled | — | Vernon Huang Ex-Co-Founder | — | — | — |
| 26 | Optura AI orchestration platform built for the healthcare industry 32Funding top 24%Talent top 38%Tech bottom 44%Global bottom 33% All 5 signals ▾Fundingtop 24% Talenttop 38% Techbottom 44% Globalbottom 33% Marketbottom 31% Funding: Raised $24.0M across 2 rounds · 2 rounds over 1 yrs (2.0/yr) Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 32/100 | $24M | 2 mo ago | Series A | — | Andy Fanning Co-Founder & CEO | WordPress Block EditorWordPressApple iCloud Mail+18 | — | — |
| 27 | CareHarmony Provider of the patient-centric chronic care management platform | $17M | 46 mo ago | Series A | 64 | — | WordPressApple iCloud MailMicrosoft 365+28 | — | — |
| 28 | Psych Hub Online platform offering video-based content for mental health management | $16M | 45 mo ago | Series A | 10 | Patrick J Kennedy Co-Founder | Builder.ioZohoPHP+30 | — | 1 partnership |
| 29 | Rootine Provider of personalized nutrition supplements | $14M | 45 mo ago | Series A | 21 | — | ShopifyTailwind CSSReact+30 | — | — |
| 30 | Spiras Health Home-based polychronic care improving health outcomes and reducing costs | $14M | 59 mo ago | Series B | 37 37 → 65 (+76%) | — | WordPress Block EditorWordPressApple iCloud Mail+22 | — | 1 expansion |
| 31 | Trilliant Health Provider of healthcare analytics platform for the healthcare industry | $13M | 58 mo ago | Series A | 113 113 → 110 (-3%) | — | HubSpot CMS HubSentryEnvoy+23 | — | — |
| 32 | AngelEye Health Provider of video, data, and analysis solutions for pediatric patient care 48Funding top 33%Growth top 37%News top 44%Tech top 48% All 8 signals ▾Fundingtop 33% Growthtop 37% Newstop 44% Techtop 48% Talentbottom 49% Marketbottom 41% Moatbottom 38% Globalbottom 37% Funding: Raised $12.2M across 6 rounds · 6 rounds over 4 yrs (1.5/yr) Growth: 1 acquisition/expansion move in 24 mo · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 48/100 | $12M | 6 mo ago | Series C | 48 | Christopher Rand CEO | WordPress Block EditorElementorWordPress+28 | — | — |
| 33 | Hashed Health Consortium of healthcare companies leveraging blockchain | $11M | 55 mo ago | Series A | 5 | — | — | — | — |
| 34 | EvidenceCare Digital clinical workflow management tool | $9M | 15 mo ago | Series B | 38 | Brian Fengler Co-Founder & CEO | WordPress Block EditorwpBakeryWordPress+32 | — | 1 partnership |
| 35 | In The Bowl Animal Health Biopharmaceuticals offering products for pet | $8M | 24 mo ago | Series A | — | Scott Holmstrom CEO | — | 75 patents Formulated animal feeds delivering antiparasitic agents for heartworm, flea control. | — |
| 36 | Azra AI and machine learning to automate oncology workflows | $8M | 12 mo ago | Series A | 26 | Chris Cashwell Founder & CEO | HubSpot CMS HubEnvoyBootstrap+18 | — | 1 launch |
| 37 | Thrive Health Tech Provider of patient and benefit management solutions for providers and employees | $7M | 10 mo ago | Seed | — | John Anderson Founder & CEO | SanityTurbopackNode.js+10 | — | — |
| 38 | Flexwise Health Online staffing platform connecting nurses and other healthcare professionals | $5M | 40 mo ago | Acquired | 14 | Kevin Godsey CEO | — | — | — |
| 39 | Clariture Digital marketing platform for healthcare organizations | $5M | 15 mo ago | Series B | 16 | — | — | — | — |
| 40 | Infusense Provider of biosensor technology for measuring drug levels in patients | $4M | 13 mo ago | Seed | 7 | Edward Chaum Founder | — | 6 patents Molecular detection biosensors and assay chemistries for identifying target compounds | — |
| 41 | UnityAI Developer of AI solutions for streamlining healthcare operations and workflows | $4M | 3 mo ago | Series A | — | Edmund Jackson Chief Executive Officer | WebflowApple iCloud MailGSAP+10 | — | — |
| 42 | ClarisHealth Provider of AI-enabled payment integrity platform | $4M | 29 mo ago | Seed | 138 138 → 135 (-2%) | Jeffrey Mcneese Chief Executive Officer | WordPressMySQLPHP+26 | — | 1 job opening |
| 43 | CareEco Provider of AI-powered revenue cycle management solutions for healthcare | $4M | 14 mo ago | Seed | — | Corey Johnson Co-Founder & CEO | Cart FunctionalitySquarespace CommerceSquarespace+14 | — | — |
| 44 | Peregrine Health Telehealth platform for mental and behavioral health disorders | $3M | 27 mo ago | Series A | — | — | — | — | — |
| 45 | HITC Provider of fall detection software for elderly people | $3M | 15 mo ago | Seed | 3 | — | — | — | — |
| 46 | Innerworld Online community platform for mental health conditions | $2M | 31 mo ago | Acquired | 14 | Noah Robinson Founder & CEO | SentryZendeskNode.js+16 | 5 patents Virtual reality platforms for mental health intervention and therapy | — |
| 47 | Swell Health Online platform offering mental health therapy services | $2M | 15 mo ago | Seed | — | Rachel Edenfield Founder & CEO | Cart FunctionalitySquarespace CommerceSquarespace+15 | — | — |
| 48 | MiCare Path Cloud-based health management tool for payers and providers | $1M | 6 mo ago | Series A | 25 | Brian Childress Co-Founder | WordPressMySQLPHP+19 | — | 1 internship |
| 49 | MSKai AI-powered spinal imaging platform for surgical outcomes | $375K | 13 mo ago | Seed | — | Adam Bruggeman Co-Founder | — | — | — |
| 50 | Mamaya Health Provider of maternal and postpartum mental health services | $215K | 10 mo ago | Seed | — | Brandon Ziemann Co-Founder & CFO & COO | WordPressMySQLPHP+28 | — | 1 partnership |
Top 12 HealthTech companies in Tennessee
#1
Series C · Knoxville, Tennessee · founded 2017 · 94 employees$54.4Mraised▾
Provider of an AI-based patient engagement and health management software for payers and doctors. The platform adapts to clinical history and social context, automating personalized communications. It facilitates engagement and navigation, aiming to close care gaps. The platform supports individualized healthcare experiences through dynamic communications. It helps individuals enroll, engage, and navigate the healthcare journeys.
- Apr 2026Series C$1.6M
- Sep 2023Series C$27M
- Jul 2022Series B$3M
- May 2022Series B$14.4M
#2
Series A · Nashville, Tennessee · founded 2024$24Mraised▾
AI orchestration platform built for the healthcare industry. It is targeting payers such as health plans, pharmacy benefit managers, and tech-enabled service organizations to scale enterprise productivity and deliver rapid, measurable ROI.
- Mar 2026Series A$17.5M
- May 2025Seed$6.5M
#3
Series D · Nashville, Tennessee · founded 2020 · 123 employees$178Mraised▾
Provider of home nursing care services
- Apr 2025Series D$97M
- Jul 2024Conventional Debt$40M
- Jul 2024Series C$55M
- May 2024Series B—
#4
Series A · Nashville, Tennessee · founded 2020 · 23 employees$25Mraised▾
Provider of in-home cancer care and nursing services
- Nov 2025Series A$2.4M
- Jan 2024Series A—
- Oct 2023Series A—
- Dec 2021Series A$25M
#5
Series C · Nashville, Tennessee · founded 2013 · 48 employees$12.2Mraised▾
Provider of video, data, and analysis solutions for pediatric patient care. It delivers integrated systems for clinical analysis, navigation, discharge management, and feeding documentation. The systems connect care teams and families to ensure a smooth transition to health. The technology offers bedside cameras with live-streaming patient viewing and secure messaging. It also provides support services to keep systems running.
- Dec 2025Series C$9M
- Mar 2025Series B$3M
- Nov 2022Series B$11.2M
- Feb 2022Seed$1M
#6
Series C · Nashville, Tennessee · founded 2016 · 1000 employees$109Mraised▾
Network of specialty clinics providing podiatry, vascular, and chronic care management. It offers treatment for medical issues through coordinated care. It focuses on addressing medical issues with treatment and preventative health. It partners with health plans and provides coordinated specialty care through clinic, home, hospital, and urgent availability.
- Feb 2025Series C$12.2M
- Jun 2023Conventional Debt—
- May 2023Series C$58.4M
- Dec 2021Series B$6.9M
#7
Series A · Nashville, Tennessee · founded 2023$4Mraised▾
Developer of AI solutions for streamlining healthcare operations and workflows. The company’s integrated AI simplifies core workflows to coordinate actions and advance patient care. It improves efficiency, quality, satisfaction, and patient experience by enabling organizations to work as one team. The AI optimizes staffing and scheduling, improves revenue capture, and manages capacity across facilities.
- Mar 2026Series A$8.5M
- Feb 2024Seed$4M
#8
Seed · Nashville, Tennessee · founded 2022$7Mraised▾
Provider of patient and benefit management solutions for providers and employees. The solutions provided by the company include patient engagement software for doctors, benefits, and perks management for employees.
- Aug 2025Seed$5M
- May 2023Seed$7M
#9
Series A · Franklin, Tennessee · founded 2022 · 26 employees$7.9Mraised▾
AI and machine learning to automate oncology workflows. It offers an AI powered oncology solution that automatically identifies, classifies, and abstracts cancer diagnoses and incidental findings from pathology and radiology reports. It manages oncology operations clinically, financially, and operationally. The features include cancer patient identification, generate, and manage radiology reports, populate data, compliance management, and more.
- Jun 2025Series A$1.9M
- Dec 2024Series A$6M
#10
Series B · Nashville, Tennessee · founded 2014 · 38 employees$9.2Mraised▾
Digital clinical workflow management tool. Their patent-pending technology works independently or can be integrated with the EMR to enhance the workflow of the Providers, allowing them to risk-stratify their patients and obtain treatment recommendations that are specific to their patient’s condition. In addition, they present data in a graphical format that is easy to share with patients and allows them to understand their treatment course. Their Enterprise solution allows hospitals to leverage their content base and provides them with the resources to easily create custom content unique to their organization. In addition, they offer multiple ways to integrate documentation with the EMR.
- Mar 2025Series B$15.4M
- Sep 2023Series A$640K
- May 2020Series A$579.6K
- May 2019Series A—
#11
Series D · Nashville, Tennessee · founded 2021 · 5 employees$504.9Mraised▾
Value-based healthcare company focused on serving rural areas. It assists clinic providers with care coordination activities including preventive screenings, scheduling patients for primary care visits and providing the clinic with the data and opportunities they need to succeed in value-based care solutions in rural America.
- Oct 2023Series D$315M
- May 2023Series D$189.9M
#12
Seed · Nashville, Tennessee · founded 2009 · 7 employees$4.4Mraised▾
Provider of biosensor technology for measuring drug levels in patients. The company offers "HemaSense" a first-in-class, hand-held device that can be used by physicians to measure drug levels directly from a drop of blood or saliva, without sample processing.
- May 2025Seed$1.4M
- Mar 2025Grant (prize money)$1.2M
- Jun 2023Grant (prize money)$1M
- Aug 2021Grant (prize money)$253.6K
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of HealthTech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Tennessee is moving
A read on the academic research around Digital Health in Tennessee — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 41 papers.
Tennessee's UTHSC, UT Knoxville, and ETSU predominantly research AI/ML and mobile health applications in healthcare, with cautiously optimistic advancement-focused findings amid notable concerns.
- University of Tennessee Health Science Center15
- University of Tennessee at Knoxville14
- East Tennessee State University4
- Tennessee Department of Health3
- VA Tennessee Valley Healthcare System3
- Public health2
- Memphis1
- Pandemic1
- Health informatics1
- Public health informatics1
- Health informatics5
- Health care5
- Telemedicine4
- Public health3
- Data science3
- Health informatics3
- Health care3
- Public health3
- Health administration2
- Nursing research2