Best Life Sciences Companies in Tennessee, United States
The 170 best Life Sciences companies in Tennessee, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: SmileDirectClub.
Our analysis of 164 Life Sciences companies
$34.7b in tracked funding; 83% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Life Sciences companies in Tennessee
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Web popularity | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | SmileDirectClub Developer of customized dental aligners | $440M | 64 mo ago | 1,360 | Jordan Katzman Co-Founder | — | — | 132 patents AI-driven 3D imaging and treatment planning for orthodontic tooth movement | — |
| 2 | Taris Biomedical Innovative medicine, therapies, and medical technology for global healthcare solutions | $109M | 101 mo ago | 14 | Robert Langer Co-Founder | — | — | 720 patents Implantable urological drug‑delivery systems for localized gemcitabine bladder cancer therapy | — |
| 3 | Pierian Biosciences Personalized cancer intelligence through innovative diagnostic assays and laboratory services | $76M | 127 mo ago | 3 | Robert Henry President and CEO | — | — | — | — |
| 4 | GI Dynamics Developer of endoscopically bile diversion barrier device | $76M | 91 mo ago | 12 | — | — | — | 704 patents Secure smart-card payment and medical data processing systems for diagnostics and dentistry | — |
| 5 | Provectus Biopharmaceuticals Developer of therapeutics to treat multiple diseases | $52M | 60 mo ago | 2 | — | — | — | — | — |
| 6 | Appello Pharmaceuticals Developer of small molecules for the treatment of neurological disorders | $40M | 53 mo ago | 1 | Brian Laden CEO | — | — | — | — |
| 7 | ProNova Innovating proton therapy solutions for cancer treatment and radiation effects testing | $38M | 134 mo ago | 82 | — | WordPressMySQLPHP+17 | Top 50M | 70 patents Compact proton therapy hardware and non‑invasive veterinary health monitoring devices | — |
| 8 | Triad Life Sciences Developer of regenerative medicine technologies | $32M | 57 mo ago | 33 | — | — | — | — | — |
| 9 | Provision Healthcare Innovating cancer care with advanced proton therapy solutions and patient-centric approach | $30M | 116 mo ago | 10 | — | WordPressMySQLPHP+16 | Top 50M | — | — |
| 10 | ABT Molecular Imaging Manufacturer of bio marker generators | $29M | 140 mo ago | — | Lynda Nutt Co-Founder | — | — | 40 patents Automated microfluidic synthesis and handling of PET radiopharmaceuticals | — |
| 11 | Amytrx Therapeutics Developer of therapies for the treatment of inflammatory diseases | $23M | 30 mo ago | 3 | Jacek Hawiger Founder | — | — | — | — |
| 12 | VenoStent Developer of a shape memory polymer stent for vascular surgery | $23M | 2 mo ago | 18 | Timothy Boire President and CEO | — | — | 15 patents 3D‑printed photocrosslinkable vinyl polymers for vascular grafts and perivascular wraps | — |
| 13 | Transnetyx Developer of automated-genotyping services for murine cell lines | $22M | 97 mo ago | 150 150 → 140 (-7%) | — | StoryblokSentryNode.js+24 | Top 5M | 31 patents High-throughput genetic and forensic DNA screening with real-time sequence detection | — |
| 14 | SweetBio Developer of wound-healing therapies for oral surgery | $17M | 42 mo ago | 7 | Kayla Rodriguez Co-Founder & CEO | Cart FunctionalitySquarespace CommerceSquarespace+14 | Top 50M | 2 patents Biomaterial compositions for bone and soft tissue regeneration therapies | 2 partnerships |
| 15 | Echo Therapeutics SDY prediction platform offering insights for lottery enthusiasts | $17M | 121 mo ago | 17 | — | — | — | — | — |
| 16 | Rootine Provider of personalized nutrition supplements | $14M | 45 mo ago | 21 | — | ShopifyTailwind CSSReact+30 | Top 10M | — | — |
| 17 | Nusirt Specialty company engaged in developing treatment for chronic diseases | $13M | 114 mo ago | 1 | — | — | — | — | — |
| 18 | AngelEye Health Provider of video, data, and analysis solutions for pediatric patient care 48Funding top 33%Growth top 37%News top 44%Tech top 48% All 8 signals ▾Fundingtop 33% Growthtop 37% Newstop 44% Techtop 48% Talentbottom 49% Marketbottom 41% Moatbottom 38% Globalbottom 37% Funding: Raised $12.2M across 6 rounds · 6 rounds over 4 yrs (1.5/yr) Growth: 1 acquisition/expansion move in 24 mo · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 48/100 | $12M | 6 mo ago | 48 | Christopher Rand CEO | WordPress Block EditorElementorWordPress+28 | Top 5M | — | — |
| 19 | BioMimetic Therapeutics Developer of therapeutics to treat musculoskeletal injuries | $11M | 203 mo ago | 58 | — | — | — | 129 patents Patents concentrated in health & consumer products | — |
| 20 | NovaLign Orthopaedics Orthopaedic implants for long bone fractures | $10M | 227 mo ago | — | Jeff Roberts CEO & President | — | — | 15 patents Modular intramedullary fixation systems for long‑bone fracture stabilization and alignment | — |
| 21 | In2Bones USA Global surgical device and equipment manufacturer focused on improving patient outcomes | $10M | 85 mo ago | — | — | — | — | 211 patents Orthopedic fixation hardware: bone plates, screws, staples, and related surgical implant systems. | — |
| 22 | Advanced Catheter Therapies Advanced catheter therapies for targeted drug delivery in peripheral vasculature | $7M | 135 mo ago | 5 | — | — | — | — | — |
| 23 | iScreen Vision Pediatric vision screening equipment and analysis | $7M | 140 mo ago | 16 | Buck Brown President & CEO | WordPressMySQLPHP+13 | Top 50M | — | — |
| 24 | Precera Bioscience Medication Management and tracking solution for healthcare providers and Payers | $7M | 103 mo ago | — | Murray Blackshear Co-Founder & Chairman | — | — | — | — |
| 25 | Ariste Medical Drug eluting surgical implants to prevent device failure | $7M | 63 mo ago | 6 | — | — | — | — | — |
| 26 | Hapten Sciences Biopharmaceutical research company developing novel products for global health | $6M | 79 mo ago | — | Raymond Hage Founder & CEO | — | — | — | — |
| 27 | PATH EX Developing blood-cleansing device to remove pathogens from circulating blood | $6M | 13 mo ago | 2 | Sinead Miller Co-Founder & CEO | — | — | 45 patents Nanoparticle-based delivery systems for malaria vaccines and therapeutic agents | — |
| 28 | Cross Roads Extremity Orthopaedic devices for complex foot & ankle problems | $5M | 59 mo ago | 20 | Chad Hollis Co-Founder | WordPressMySQLPHP+18 | Top 50M | — | — |
| 29 | Hypermed Hyperspectral imaging for tissue oximetry, advancing healthcare with innovative technology | $5M | 99 mo ago | 7 | — | — | — | 27 patents Hyperspectral/multispectral medical imaging for tissue oxygenation and diabetic foot diagnostics | — |
| 30 | Bryleos Developer of therapeutics for neurological disorders | $5M | 36 mo ago | 4 | Wendy Komac Co-Founder & CEO | — | — | — | — |
| 31 | ExtraOrtho Orthopedic external fixation system | $4M | 179 mo ago | — | Brian Austin President & CEO | — | — | 41 patents Advanced locking and articulation mechanisms for orthopedic external fixation clamps | — |
| 32 | IQuity Provider of RNA-based diagnostics for autoimmune disorders | $4M | 45 mo ago | 9 | — | — | — | 12 patents Analyzing disease biomarkers via lncRNA expression and claims data for diagnosis | — |
| 33 | IDBiologics Developer of antibodies to treat infectious diseases | $4M | 63 mo ago | 1 | James Crowe Co-Founder | — | — | — | — |
| 34 | Molecular Sensing Innovative molecular sensing for drug discovery and development | $4M | 142 mo ago | 11 | Scot Weinberger Co-Founder | — | — | 30 patents Interferometric biosensing platforms for label-free detection of biomolecular interactions | — |
| 35 | Lynch Biologics Developer of regenerative medicines for orthopaedic, periodontal and oral treatments | $4M | 29 mo ago | 9 | Sam Lynch Founder & CEO | Cart FunctionalityWooCommerceWordPress+23 | Top 50M | — | — |
| 36 | Healing Innovations Robotic neurorehabilitation technology improving mobility and independence for neurological injury recovery | $3M | 19 mo ago | 11 | — | WebflowTypekitcore-js+14 | Top 50M | — | 2 job openings · 1 partnership · 1 expansion |
| 37 | Cagenix Titanium dental frameworks | $3M | 178 mo ago | 26 | Carl Schulter Founder | — | — | 33 patents Design and manufacturing of dental implant frameworks and prosthetic overdenture systems. | — |
| 38 | Insight Genetics Molecular diagnostics company that is working to enhance the diagnosis, monitoring and treatment of cancer. | $3M | 127 mo ago | 3 | — | — | — | 42 patents ALK fusion detection and targeted therapy diagnostics for cancer | — |
| 39 | Quire Data AI solutions for healthcare and beyond, enhancing efficiency and growth | $3M | 150 mo ago | 8 | — | — | — | — | — |
| 40 | VenX Medical Develops devices for the treatment of spider and reticular veins | $3M | 144 mo ago | — | David Barella ex-President & CEO | — | — | — | — |
| 41 | Silicone Arts Laboratories Replica of human eye and Scar filler to fill skin defects | $3M | 134 mo ago | 5 | — | — | — | — | — |
| 42 | Rx Bio Developing proprietary products for the treatment of gastrointestinal (GI) Acute Radiation Syndrome. | $2M | 69 mo ago | 8 | Shannon McCool CEO & President | — | — | — | — |
| 43 | Etheros Pharmaceuticals Developer of small molecule enzyme mimetics for neuroprotection and healthspan extension | $2M | 16 mo ago | — | Laura Dugan Co-Founder | — | — | — | — |
| 44 | NellOne Regenerative medicine company restoring damaged tissue to its pre-injury state | $2M | 62 mo ago | 4 | Tracy Warren Co-Founder & ex-CEO | — | — | — | — |
| 45 | Tavo Biotherapeutics Developer of therapeutics to treat ophthalmic diseases to preserve and enhance vision through injectionless… | $1M | 21 mo ago | — | Monica Jablonski Founder | — | — | — | — |
| 46 | Winter Innovations Manufacturer of surgical sutures and needle products | $781K | 39 mo ago | 5 | Lia Winter Founder & CEO | — | — | — | 1 launch |
| 47 | EndoTheia Developer of medical devices for endoscopic surgery | $500K | 16 mo ago | 7 | — | WixSentryBootstrap+10 | Top 50M | 20 patents Flexible endoscopic devices and stone extraction tools for minimally invasive surgery. | — |
| 48 | Orion Therapeutics Developer of RNA therapy and vaccine for vascular diseases | $300K | 23 mo ago | — | Richard Fisher Founder & CEO | — | — | — | — |
| 49 | Virtuoso Surgical Developer of robotic endoscopic surgery system | $180K | 4 mo ago | 10 | — | WordPressMySQLPHP+27 | Top 50M | 28 patents Robotic concentric‑tube platforms for minimally invasive surgery and automated suturing. | — |
| 50 | Diatech Diabetes Providing a software platform for monitoring insulin delivery | $150K | 22 mo ago | 6 | Luis Blanco Co-Founder & Chief Technology Officer | — | — | 6 patents Detecting and monitoring disruptions in medical fluid delivery infusion devices | — |
Top 12 Life Sciences companies in Tennessee
#1
Series A · Nashville, Tennessee · founded 2017 · 18 employees$22.8Mraised▾
Developer of a shape memory polymer stent for vascular surgery. The SelfWrap, is an external stent, used for venous access in hemodialysis patients. The stent, is a polymer wrap, provides a mechanical support and reduces vein collapse, at the point of surgery, by promoting vein growth in dialysis patients.
- Apr 2026Series A$10M
- May 2025Grant (prize money)$2.5M
- Apr 2025Grant (prize money)$2.5M
- Jun 2024Series A$4M
#2
Series C · Nashville, Tennessee · founded 2013 · 48 employees$12.2Mraised▾
Provider of video, data, and analysis solutions for pediatric patient care. It delivers integrated systems for clinical analysis, navigation, discharge management, and feeding documentation. The systems connect care teams and families to ensure a smooth transition to health. The technology offers bedside cameras with live-streaming patient viewing and secure messaging. It also provides support services to keep systems running.
- Dec 2025Series C$9M
- Mar 2025Series B$3M
- Nov 2022Series B$11.2M
- Feb 2022Seed$1M
#3
Series A · Nashville, Tennessee · founded 2016 · 2 employees$6.3Mraised▾
PATH EX is developing a blood-cleansing device to remove pathogens from circulating blood. They are developing an extracorporeal blood-cleansing device designed to remove multi-drug resistant bacteria and bacterial endotoxin from circulating blood. its Pre-clinical studies demonstrated a reduction of 95% bacteria in a single pass.
- May 2025Series A$5M
- Sep 2021Grant (prize money)$25K
- Oct 2020Grant (prize money)$100K
- Jun 2018Grant (prize money)$910K
#4
Series A · Nashville, Tennessee · founded 2016 · 10 employees$179.8Kraised▾
Developer of robotic endoscopic surgery system. The system delivers robotically controlled, needle-sized manipulators to apprehend, manipulate, and cut tissues. It is used in various areas of surgery, including neurologic, thoracic, orthopedic, urologic, and gynecologic procedures.
- Feb 2026Series A$2.9M
- Nov 2023Grant (prize money)$1.8M
- Aug 2023Seed$179.8K
#5
Deadpooled · Nashville, Tennessee · founded 2014 · 1360 employees$439.5Mraised▾
Developer of customized dental aligners. The online platform can be used to order the aligners by taking teeth impressions and the company develops customized invisible aligners for the users.
- Feb 2021Post IPO$350M
- Oct 2018Series C$380M
- Jul 2017Series B$12.8M
- 2016Series B$46.7M
#6
Funding Raised · Nashville, Tennessee · founded 2018 · 11 employees$3.3Mraised▾
Robotic neurorehabilitation technology improving mobility and independence for neurological injury recovery. This company develops market-leading robotic technology to increase access to better rehabilitation. Their flagship product is a 3-in-1 rehab station facilitating seated, standing, and walking neurorehabilitation. This innovative approach caters to a wide variety of use cases, treatment programs, and clinics. They are committed to pushing boundaries in neuro rehabilitation through cutting-edge technology and research. They foster collaboration with patients, staff, and partners to create tailored solutions. The company empowers patients and staff to take control of their rehabilitation journey and achieve their goals. They serve inpatient, outpatient, skilled nursing, LTACH, and community wellness centers, addressing conditions like stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s, and cerebral palsy.
- Oct 2024Grant (prize money)$2M
- Sep 2024Grant (prize money)$1M
- Aug 2020Grant (prize money)$223.4K
- May 2018Conventional Debt$75K
#7
Seed · Nashville, Tennessee · founded 2022$1.7Mraised▾
Developer of small molecule enzyme mimetics for neuroprotection and healthspan extension. It offer drugs which mimic the endogenous enzymes, superoxide dismutase and catalase, that prevent oxidative and inflammatory injury to which neural tissue is sensitive.
- Jan 2025Seed$600K
- Nov 2023Seed$300K
- Feb 2023Seed$775K
#8
Series A · Nashville, Tennessee · founded 2014 · 3 employees$22.9Mraised▾
Developer of therapies for the treatment of inflammatory diseases. The lead therapeutic peptide AMTX-100 is bioengineered from human protein sequences that modulate the immune system by a natural process, reducing pathogenesis in a range of conditions.
- Dec 2023Series A$725K
- May 2022Series A$18M
- Aug 2020Series A$3.6M
- Jul 2016Seed$600K
#9
Funding Raised · Memphis, Tennessee · founded 2024$1.3Mraised▾
Developer of therapeutics to treat ophthalmic diseases to preserve and enhance vision through injectionless therapies. It offers topical microemulsion technology that preserves and enhances sight for the treatment of vision loss, AMD, inherited retinal dystrophies, and glaucoma.
- Sep 2024Grant (prize money)$1.1M
- Jun 2024Grant (prize money)$280K
#10
Seed · Nashville, Tennessee · founded 2018 · 7 employees$500Kraised▾
Developer of medical devices for endoscopic surgery. The company harnesses the power of micro-machined smart materials to create highly dexterous manipulators to improve therapeutic outcomes in complex flexible endoscopic procedures.
- Feb 2025Grant (prize money)$1.4M
- Sep 2024Seed$500K
#11
Public · Knoxville, Tennessee · founded 2002 · 2 employees$51.8Mraised▾
Developer of therapeutics to treat multiple diseases. The company's product line include PV-10 is a non-pyrogenic solution of Rose Bengal disodium for the treatment of Melanoma, Melanoma in combination with Keytruda, recurring breast cancer, and pediatric solid tumors. Also, it is developing PH-10 for the treatment of Psoriasis and Atopic Dermatitis.
- May 2021Grant (prize money)$2.5M
- Apr 2014Post IPO$3.4M
- Oct 2013Post IPO$7.8M
- Sep 2013Post IPO$7.8M
#12
Acquired · Lexington, Tennessee · founded 2008 · 14 employees$108.9Mraised▾
Innovative medicine, therapies, and medical technology for global healthcare solutions. This organization focuses on developing and delivering transformational medicines and medical innovations across various healthcare areas. These areas include oncology, immunology, neuroscience, and cardiopulmonary, with a commitment to rigorous science and patient compassion. They pioneer new medicines from lab to life, addressing devastating diseases and improving patient care globally. The company is dedicated to research, clinical trials, and providing resources for both healthcare professionals and patients. They are leading the way in medical innovation, with a focus on precision medicine, data science, and digital health to create a healthier future.
- Dec 2017Series B$25M
- Oct 2015Series B$32M
- Apr 2013Series B$13.5M
- Apr 2011Series B$18.4M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Life Sciences coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Biotechnology in Tennessee is moving
A read on the academic research around Biotechnology in Tennessee — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 192 papers.
Tennessee's University of Tennessee campuses lead mildly optimistic biotechnology research (stance 0.09) dominated by taxonomic and subterranean biodiversity studies, with recent output surging sharply post-2020.
- University of Tennessee at Chattanooga140
- University of Tennessee at Knoxville28
- University of Tennessee Health Science Center9
- Tennessee State University6
- Tennessee Technological University4
- Gene expression2
- Gene2
- Apoptosis2
- Bursting1
- Genetics1
- Bacteria2
- Oxidative stress2
- Downregulation and upregulation2
- Antibiotic resistance2
- Identification (biology)2
- Antimicrobial2
- Dairy cattle2
- Quality (philosophy)2
- Biofuel2
- Food spoilage1
Common questions
Rohit lives in the feed. He covers what's moving right now — the funding rounds, launches and shifts breaking across the trade press — and ties them back to where the sector is heading.