Best HealthTech Companies in Illinois, United States
The 726 best HealthTech companies in Illinois, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: VillageMD.
Our analysis of 305 HealthTech companies
$32.1b in tracked funding; 95% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best HealthTech companies in Illinois
| # | Company | Disclosed funding | Last round | Stage | Employees | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | VillageMD Provider of value-based primary care management tools for providers | $1.2B | 72 mo ago | Acquired | 3,107 3,107 → 1,684 (-46%) · sector median +72% | Tim Barry Co-Founder & CEO | HubSpot CMS HubApple iCloud MailMicrosoft 365+19 | — | — |
| 2 | Tempus 🦄 Developer of genomic testing and artificial intelligence tools for medicine | $1.1B | 43 mo ago | Public | 772 | Eric Lefkofsky Founder & CEO | Cart FunctionalityWordPressApple iCloud Mail+33 | 594 patents AI-powered medical diagnostics: imaging biomarkers, liquid biopsy genomics, and cardiac ECG analysis | — |
| 3 | RLDatix GRC software solutions for the healthcare industry | $736M | 53 mo ago | Late Stage | 1,400 | Dan Michelson CEO | WordPressApple iCloud MailMySQL+33 | — | — |
| 4 | Outcome Health 🦄 Online patient engagement tool for providers | $533M | 107 mo ago | Acqui-Hired | 221 | — | — | — | — |
| 5 | Xeris Pharmaceuticals Developer of liquid-stable injectables for the delivery of drugs | $155M | 53 mo ago | Public | 294 294 → 506 (+72%) · sector median +72% | Steve Prestrelski Co-Founder & CSO | DrupalApple iCloud MailPHP+32 | 249 patents Stable drug formulations, especially levothyroxine, using aprotic polar solvents | 1 internship · 1 award |
| 6 | Evozyne Developer of proteins using protein engineering technology | $144M | 33 mo ago | Series B | 73 | Rama Ranganathan Co-Founder & CSO | WordPressMySQLPHP+17 | 2 patents AI-driven design of synthetic proteins for protein engineering applications | — |
| 7 | HealthJoy Web and smart phone based teleconsultation platform | $113M | 43 mo ago | Series D | 141 141 → 285 (+102%) · sector median +72% | Doug Morse-Schindler President & Co-Founder | HubSpot CMS HubApple iCloud MailGoogle Workspace+27 | — | 2 launchs |
| 8 | Pathos 🦄 Provider of AI based drug discovery platform for drug development | $102M | 14 mo ago | Series D | 12 | Ryan Fukushima Co-Founder | DudaApple iCloud MailGoogle Workspace+14 | — | 2 job openings · 1 internship |
| 9 | Upfront Healthcare Provider of data analytics platform to help clinics schedule and allocate resources | $96M | 36 mo ago | Acquired | 45 45 → 26 (-42%) · sector median +72% | Carrie Kozlowski COO & Co-Founder | Froala EditorSalesforceMicrosoft ASP.NET+10 | — | — |
| 10 | NOCD Mobile app for treating obsessive-compulsive disorder | $85M | 40 mo ago | Series C | 14 | Evan Bogart Founder & CEO | Node.jsHeadless UITailwind CSS+28 | — | — |
| 11 | Cylinder Health Digital health platform offering solutions for individuals with digestive health issues | $78M | 32 mo ago | Series B | — | Bill Snyder Co-Founder & CEO | WordPressApple iCloud MailGoogle Workspace+30 | — | — |
| 12 | Nucle AI AI-assisted platform for image analysis | $60M | 26 mo ago | Series B | 9 | Lotan Chorev Co-Founder and VP R&D | — | — | — |
| 13 | HomeThrive Family health benefits solutions for senior care | $59M | 22 mo ago | Series B | 65 65 → 80 (+23%) · sector median +72% | David Greenberg Co-Founder & Co-CEO | WordPressApple iCloud MailGoogle Workspace+33 | — | 2 partnerships |
| 14 | Janus AI AI and SaaS-based revenue cycle management tool for healthcare providers | $56M | 20 mo ago | Series B | 94 94 → 110 (+17%) · sector median +72% | Brendan Downing Co-Founder & CEO | — | 28 patents Hardware security and access control solutions for computing devices and network interfaces | 3 job openings · 2 partnerships |
| 15 | Visibly Online vision test technology for providers | $50M | 38 mo ago | Series B | 29 29 → 62 (+114%) · sector median +72% | — | Apple iCloud MailGoogle WorkspaceNode.js+15 | 19 patents Camera‑based ophthalmic diagnostics for refraction, astigmatism, and visual‑field assessment | — |
| 16 | Sibel Health Developer of wireless medical monitoring devices for clinical and remote use 32Funding top 25%Moat top 31%Talent bottom 49%Growth bottom 42% All 8 signals ▾Fundingtop 25% Moattop 31% Talentbottom 49% Growthbottom 42% Techbottom 41% Marketbottom 38% Globalbottom 36% Newsbottom 17% Funding: Raised $50.0M across 6 rounds · 6 rounds over 6 yrs (1.0/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 32/100 | $50M | 14 mo ago | Series C | 47 | Steve Xu Co-Founder & CEO | WordPressApple iCloud MailGoogle Workspace+24 | — | 1 award |
| 17 | Kalderos Online platform to coordinate and manage drug discount programs | $50M | 17 mo ago | Series C | 110 | James William Schuyler Co-Founder | WebflowSentryZendesk+21 | 2 patents Healthcare marketplace financial transaction platforms for patient payments and secondary trades | 1 partnership |
| 18 | Artisight Provider of IoT solutions for the healthcare industry | $42M | 12 mo ago | Series B | 63 63 → 139 (+121%) · sector median +72% | Garrett Larance Co-Founder | WordPressApple iCloud MailGoogle Workspace+28 | 3 patents Remote monitoring and communication systems for IoT devices | 2 partnerships · 1 award |
| 19 | Waltz Health AI-based medical prescription cost management tool for payers and consumers | $35M | 18 mo ago | Acquired | 32 32 → 39 (+22%) · sector median +72% | Jonathon Thierer Co-Founder and Senior Vice President of Product | MUIAzure Front DoorReact+9 | — | — |
| 20 | Blueprint Provider of AI-powered documentation and insights for mental health therapists | $32M | 14 mo ago | Series B | 4 | Danny Freed Founder & CEO | WebflowSentryQuill+33 | — | — |
| 21 | KeyCare Digital teleconsultation tool for providers and patients 45Funding top 25%News top 36%Moat top 39%Growth top 45% All 8 signals ▾Fundingtop 25% Newstop 36% Moattop 39% Growthtop 45% Techtop 45% Talentbottom 49% Marketbottom 40% Globalbottom 37% Funding: Raised $29.5M across 4 rounds · 4 rounds over 4 yrs (1.0/yr) News: 2 BI events in 12 mo (of 4 tracked, 2 types) · Top themes: Funding, Capital raise rank vs industry peers · Fliar Intelligence Index 45/100 | $29M | 3 mo ago | Series A | 21 | Lyle Berkowitz Founder & CEO | WebflowSalesforceHubSpot+18 | — | — |
| 22 | Third Eye Health Provider of virtual care and coordination software for hospitals | $25M | 33 mo ago | Series A | 50 | Lucas Baran Co-Founder & CTO | WordPressApple iCloud MailMicrosoft 365+20 | — | 1 job opening · 1 partnership |
| 23 | CancerIQ Cloud-based platform to doctors, for identifying cancer risk patients and delivering care plans | $24M | 21 mo ago | Series B | 78 | Feyi Olopade CEO | SkolengoSentryZendesk+17 | — | 1 launch |
| 24 | Prenosis AI-based precision diagnostic platform for acute care | $20M | 4 mo ago | Series A | 29 | Rashid Bashir Co-Founder | WordPressApple iCloud MailMicrosoft 365+27 | 21 patents AI-driven clinical risk prediction, dataset normalization, and personalized therapy dashboards | — |
| 25 | Thoughtful AI-powered healthcare administration platform to automate tasks | $20M | 14 mo ago | Series A | 16 | Alex Zekoff Co-Founder & CEO | WebflowZohoYouTube+29 | — | — |
| 26 | Praia Health Provider of a platform as a service technology for patient engagement | $20M | 19 mo ago | Series A | — | Justin Dearborn Founder & CEO | — | — | — |
| 27 | Dina Provider of an AI-based senior care coordination software for healthcare organizations | $18M | 28 mo ago | Acquired | 38 38 → 68 (+79%) · sector median +72% | Ashish Shah Co-Founder & CEO | — | — | — |
| 28 | BrightOutcome Improving patient health outcomes with patient-centered web applications and electronic PRO | $17M | 5 mo ago | Funding Raised | 6 | DerShung Yang Founder | — | — | — |
| 29 | SimBioSys Provider of AI-based decision-making and cancer diagnosis tool for healthcare professionals | $15M | 17 mo ago | Series A | 46 | Joseph Peterson Founder and CTO | WordPressApple iCloud MailMicrosoft 365+27 | 12 patents Patient-specific 3D tumor modeling and perfusion MRI-based cancer prognostics | — |
| 30 | SonarMD Cloud-based care management solutions for chronic conditions 48Funding top 32%Growth top 35%Talent top 38%Tech top 39% All 7 signals ▾Fundingtop 32% Growthtop 35% Talenttop 38% Techtop 39% Producttop 46% Marketbottom 30% Globalbottom 29% Funding: Raised $14.3M across 5 rounds · 5 rounds over 8 yrs (0.6/yr) Growth: Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 48/100 | $14M | 3 mo ago | Series B | 25 | Lawrence Kosinski Founder at SonarMD | WordPressApple iCloud MailMicrosoft 365+21 | — | — |
| 31 | Cardio Diagnostics AI based platform offering cardiovascular medicine | $14M | 28 mo ago | Public | — | Robert Philibert Co-Founder | WordPress Block EditorCart FunctionalityBuilder.io+19 | — | — |
| 32 | Rhaeos Developer of a noninvasive device to monitor CSF and manage hydrocephalus 35Talent top 28%Funding top 32%Patents top 32%Innovation top 34% All 9 signals ▾Talenttop 28% Fundingtop 32% Patentstop 32% Innovationtop 34% Moattop 38% Globalbottom 40% Marketbottom 24% Techbottom 23% Newsbottom 18% Talent: 4 named leaders on record · 4 C-suite/founder profiles curated Funding: Raised $12.8M across 13 rounds · 13 rounds over 6 yrs (2.2/yr) rank vs industry peers · Fliar Intelligence Index 35/100 | $13M | 14 mo ago | Series A | 10 10 → 20 (+100%) · sector median +72% | Amit Ayer Co-Founder | — | 16 patents Medical wearable thermal sensing and non‑invasive fluid flow monitoring devices | — |
| 33 | FreshAir Sensor Developer of an air-sensor device to detect tobacco and marijuana smoke 55Talent top 22%Moat top 31%Innovation top 35%Growth top 35% All 10 signals ▾Talenttop 22% Moattop 31% Innovationtop 35% Growthtop 35% Fundingtop 38% Patentstop 38% Producttop 40% Techtop 48% Marketbottom 32% Globalbottom 31% Talent: Analyst team rating 5/5 · 3 named leaders on record Moat: Editorial + unicorn rating 7/10 · IP moat: 15 patents rank vs industry peers · Fliar Intelligence Index 55/100 | $12M | 18 mo ago | Series B | 36 | John O'Toole Co-Founder | WordPressMySQLPHP+30 | 15 patents Patents concentrated in computing, sensing & instrumentation | — |
| 34 | Fello Online platform offering mental health support through peer to peer connections | $10M | 18 mo ago | Seed | — | Jeff Werring Co-Founder | WebflowPostHogGoogle Analytics+18 | — | — |
| 35 | ResetSmile Online platform offering a custom tooth replacement device | $10M | 13 mo ago | Series A | — | Clay Teufel Co-Founder | — | — | — |
| 36 | BiomeSense Developer of AI-enabled technology platform for microbiome data generation and analysis | $8M | 15 mo ago | Seed | 5 | Jack Gilbert Co-Founder | WebflowGSAPLenis+11 | 11 patents Microbiome diagnostic tools for stool sample collection and analysis | — |
| 37 | Carallel Digital health care planning and coordination tool for providers and employees | $8M | 17 mo ago | Series A | 26 | Hillary Ebach Co-Founder | WordPress Block EditorWordPressApple iCloud Mail+37 | — | — |
| 38 | When Insurance Provider of health insurance services for employees | $7M | 6 mo ago | Series A | 8 | — | SentryZendeskApple iCloud Mail+18 | — | — |
| 39 | Adoreal Provider of an aesthetics companion that offers various treatments and procedures | $6M | 20 mo ago | Series A | — | Thomas Fuller Co-Founder & CEO | TypeScriptGoogle MapsZone.js+15 | — | 1 partnership |
| 40 | Hoodie Analytics Provider of market analytics software for cannabis dispensary management | $5M | 23 mo ago | Series A | — | Wes Shepherd CEO | Cart FunctionalityWordPressMySQL+26 | — | 1 launch |
| 41 | Adaptive Testing Technologies Provider of software for mental health assessment for patients | $5M | 16 mo ago | Funding Raised | 5 | David Weiss Founder | — | — | — |
| 42 | TeleTeachers Online platform offering e-learning services 29Funding top 38%Talent bottom 49%Market bottom 42%Global bottom 29% All 4 signals ▾Fundingtop 38% Talentbottom 49% Marketbottom 42% Globalbottom 29% Funding: Raised $4.3M across 3 rounds · 3 rounds over 6 yrs (0.5/yr) Talent: 1 named leader on record · 1 C-suite/founder profile curated rank vs industry peers · Fliar Intelligence Index 29/100 | $4M | 8 mo ago | Series A | 28 | Emily Smith Founder & CEO | — | — | — |
| 43 | Grove Biopharma Developer of AI-based drug modality platform for protein-based drugs | $4M | 13 mo ago | Series A | 7 | Geoff Duyk Co-Founder | WebflowGSAPcore-js+10 | — | — |
| 44 | Beacon Developer of intelligent disinfection technology for air and surfaces | $4M | 13 mo ago | Series A | — | Andrea Clark Founder & Head of Product and Research | Wix eCommerceWixSentry+19 | — | 1 launch |
| 45 | Neopenda Provider of wearable neonatal signs monitor 16Moat top 38%Funding top 42%Tech top 43%Talent bottom 49% All 12 signals ▾Moattop 38% Fundingtop 42% Techtop 43% Talentbottom 49% Productbottom 47% Growthbottom 43% Globalbottom 37% Innovationbottom 36% Patentsbottom 25% Marketbottom 22% Fin. healthbottom 19% Newsbottom 18% Moat: Editorial + unicorn rating 7/10 · IP moat: 3 patents Funding: Raised $2.7M across 12 rounds · 12 rounds over 8 yrs (1.5/yr) rank vs industry peers · Fliar Intelligence Index 16/100 | $3M | 1 mo ago | Seed | 14 | Teresa Cauvel Co-founder and CTO | WixSentryBootstrap+14 | 3 patents Wearable neonatal vital‑sign monitoring systems | 1 job opening · 1 launch · 1 expansion |
| 46 | Planbase Scheduling and workforce management software for healthcare providers | $3M | 7 mo ago | Seed | — | Joe S Co-Founder | — | — | 1 launch |
| 47 | RxSaveCard Platform offering pharmacy benefit solution | $2M | 7 mo ago | Seed | — | Chris Crawford Founder & CEO | WordPressMySQLPHP+29 | — | — |
| 48 | HumanImage Developer of three-dimensional imaging device for skin lesion and cancer tracking | $2M | 2 mo ago | Seed | — | David Teplica Founder & CEO & CMO | — | 5 patents Three‑dimensional body surface imaging for medical and fitness avatar creation | — |
| 49 | Graymatter Labs Online paltform offering nutritional supplemnets to improve health 62Growth top 28%Talent top 38%Tech top 44%Funding bottom 48% All 5 signals ▾Growthtop 28% Talenttop 38% Techtop 44% Fundingbottom 48% Globalbottom 48% Growth: Web rank 5,000,000 → 1,000,000 YoY · Fresh capital in last 24 mo Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 62/100 | $1M | 7 mo ago | Seed | — | Jim Phillips Co-Founder | Cart FunctionalityShopifyEasyGift+38 | — | — |
| 50 | Altris AI-based diagnostic solution for ophthalmologists | $1M | 16 mo ago | Seed | 15 | Andrey Kuropyatnyk Founder & CEO | WordPressMySQLPHP+26 | — | 1 launch |
Top 12 HealthTech companies in Illinois
#1
Series A · Chicago, Illinois · founded 2020 · 21 employees$29.5Mraised▾
Digital teleconsultation tool for providers and patients. It offers Epic-based virtual care platform which offer virtual care network, patients can book appointments through the MyChart portal or call center.
- Mar 2026Series A$27.4M
- Apr 2025Series A$27.7M
- Jan 2023Series A$27M
- Mar 2022Seed$2.5M
#2
Series A · Chicago, Illinois · founded 2014 · 29 employees$20Mraised▾
AI-based precision diagnostic platform for acute care. It offers Immunix precision diagnostics and evidence generation platform that leverages machine learning algorithms, clinical data, deep biological data, and biobanked sample to identify and treat patient with sepsis.
- Jan 2026Series A$20M
- Sep 2024Grant (prize money)$700K
- Jul 2023Grant (prize money)$4.8M
- Jun 2023Grant (prize money)$4.9M
#3
Series B · Chicago, Illinois · founded 2009 · 25 employees$14.3Mraised▾
Cloud-based care management solutions for chronic conditions. It offers a care coordination program that proactively connects patients with care teams in real time and provides wrap-around services to help patients manage their individual health needs. Their platform collects patient health data through surveys and analyzes it to track the status of improvement. They generate scores from the survey and send alerts to doctors.
- Feb 2026Series B$3M
- Dec 2024Series A$2.2M
- Jul 2024Conventional Debt$1M
- May 2023Series A$4.3M
#4
Funding Raised · Buffalo Grove, Illinois · founded 2003 · 6 employees$16.8Mraised▾
Improving patient health outcomes with patient-centered web applications and electronic PRO. The company focuses on enhancing patient care across the continuum through technology. They provide patient-centered web applications designed to engage, inform, and empower individuals in their healthcare journey. The company is dedicated to leading the shift toward electronic Patient-Reported Outcomes (PRO) to improve healthcare delivery. They partner with health researchers, care providers, and IT system vendors. The company offers software solutions to improve patient engagement and data-driven insights for better healthcare management. They are a B2B company offering SaaS based solutions.
- Dec 2025Grant (prize money)$399.8K
- Sep 2023Grant (prize money)$1.9M
- Sep 2022Grant (prize money)$1.7M
- Jul 2020Grant (prize money)$350.4K
#5
Seed · Chicago, Illinois · founded 2015 · 14 employees$2.7Mraised▾
Provider of wearable neonatal signs monitor. The device is a small low-cost neonatal vital signs monitor integrated into a baby hat and uses a simple sensor array to measure heart rate, respiratory rate, blood oxygen saturation, and temperature. The sensors are powered by rechargeable batteries, and wirelessly transmit data to a central monitor which alerts attending healthcare professionals when a newborn is in immediate danger. It is intended for critically ill newborns being cared for in hospitals in low-resource countries such as Uganda.
- Apr 2026Conventional Debt$35K
- Nov 2024Conventional Debt$200K
- Sep 2022Conventional Debt$700K
- Apr 2021Seed$1.4M
#6
Pathos 🦄Series D · Chicago, Illinois · founded 2022 · 12 employees$102Mraised▾
Provider of AI based drug discovery platform for drug development. The company licenses or co develops clinical stage therapeutics, optimizing patient selection strategies for accelerated, biomarker driven drug development. It utilizes real world oncology data and patient derived functional genomic data to identify and validate compelling biology, aiming to develop efficacious drugs for patients with unmet needs and enhance patient outcomes.
- Apr 2025Series D$283M
- Oct 2024Series C$62M
#7
Series B · Glenview, Illinois · founded 2017 · 63 employees$42Mraised▾
Provider of IoT solutions for the healthcare industry. Its offerings include connected cameras and an IoT-based sensor network that facilitates inpatient monitoring, fall prevention, and bed management. Its features include multi-screen monitoring in real-time, ML-based movement detection, automated alarms, and pre-recorded patient alerts, two-way audio communication, and customization.
- May 2025Grant (prize money)$377.6K
- Jan 2024Series B$42M
- Jul 2022Grant (prize money)$377.6K
- Aug 2019Grant (prize money)$1.9M
#8
Series A · Chicago, Illinois · founded 2020 · 8 employees$7Mraised▾
Provider of health insurance services for employees. It offers health and financial wellness insurance services for individuals and families. Its employees can view their benefit amount and get answers to common health insurance questions on the platform. It provides services to the employees after a job loss with their COBRA continuation plan.
- Dec 2025Series A$10.2M
- Apr 2025Seed$50K
- Jun 2024Seed$4.6M
- 2023Seed$2.4M
#9
Series C · Niles, Illinois · founded 2018 · 47 employees$50Mraised▾
Developer of wireless medical monitoring devices for clinical and remote use. The company provides devices and data integration for healthcare delivery and patient outcomes. It focuses on vital signs monitoring for neonatal, maternal, and adult care. The company offers technology for clinical trials, research, and hospital settings.
- Mar 2025Series C$30M
- May 2024Grant (prize money)$17.5M
- Aug 2022Series B$33M
- Dec 2021Grant (prize money)$150K
#10
Seed · Chicago, Illinois · founded 2021$1.5Mraised▾
Developer of three-dimensional imaging device for skin lesion and cancer tracking. The company develops AnthroCam, a 3D imaging device that creates high-resolution, life-sized avatars of skin surfaces using non-invasive visible light technology. It enables tracking subtle changes for early skin cancer detection, rooted in decades of anatomic imaging research.
- Mar 2026Seed$1.5M
#11
Series B · Chicago, Illinois · founded 2019 · 4 employees$31.9Mraised▾
Provider of AI-powered documentation and insights for mental health therapists. It offers AI-assisted progress notes and treatment plans, generating these documents from session recordings. The platform provides real-time clinical assistance before, during, and after client sessions, including reminders, suggestions, and post-session resources. It integrates with existing electronic health record (EHR) systems and prioritizes data security and privacy, adhering to relevant compliance standards. The service aims to streamline workflows and improve the efficiency of mental health practices.
- Apr 2025Series B$15M
- Jun 2023Series A$6.6M
- Jun 2023Series A$9M
- Apr 2019Seed$1.3M
#12
Series C · Chicago, Illinois · founded 2016 · 110 employees$49.9Mraised▾
Provider of an online platform for managing drug discount programs. The platform tracks and records the validation tests of data and custom validation tests. it also offers features such as compliance issues verification, claims level visibility, transparency in the drug supply chain, and communication for dispute resolution among the affected parties.
- Dec 2024Series C$26.4M
- Sep 2022Series B$14.9M
- Jun 2020Series B$28M
- May 2019Series A$7M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of HealthTech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Digital Health in Illinois is moving
A read on the academic research around Digital Health in Illinois — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 149 papers.
UIC and UIUC lead Illinois's cautiously contested digital-health research, focusing on telehealth, EHR systems, and digital mental health, with concern-dominant but slightly optimistic overall stance.
- University of Illinois Chicago68
- University of Illinois Urbana-Champaign30
- Western Illinois University11
- Illinois College10
- Illinois Department of Public Health9
- Wearable computer6
- Health care5
- Wearable technology3
- Big data3
- Precision medicine3
- Wearable computer1→4
- Remote patient monitoring1→3
- Health care2→20
- Health informatics1→9