Best Life Sciences Companies in Colorado, United States
The 368 best Life Sciences companies in Colorado, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Somalogic.
Our analysis of 164 Life Sciences companies
$34.7b in tracked funding; 83% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Life Sciences companies in Colorado
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Somalogic Developer of protein-based assays for life science research | $664M | 65 mo ago | 319 | 1999 | Larry Gold CEO | 796 patents Aptamer-based multiplexed protein/biomarker detection and quantitative proteomics assays. | — |
| 2 | Enveda 🦄 AI-based platform to decipher the chemistry of nature and develop new medicines 72Funding top 12%Moat top 32%Growth top 35%Market top 44% All 8 signals ▾Fundingtop 12% Moattop 32% Growthtop 35% Markettop 44% AItop 45% Talentbottom 49% Globalbottom 48% Techbottom 46% Funding: Raised $505M across 9 rounds · 9 rounds over 7 yrs (1.3/yr) Moat: Unicorn · 10 curated direct competitors tracked rank vs industry peers · Fliar Intelligence Index 72/100 | $505M | 9 mo ago | — | 2019 | Viswa Colluru Founder & CEO | — | — |
| 3 | Inscripta Developer of gene editing technology for research | $499M | 42 mo ago | 176 | 2015 | Andrew Garst Co-Founder | 654 patents CRISPR-based genome editing platforms and microbial metabolic engineering for isoprenoid production | — |
| 4 | Enveda Developer of an AI-enabled drug discovery platform to treat fibrosis or neurodegenerative disease | $224M | 24 mo ago | 175 | 2019 | Viswa Colluru Founder & CEO | — | 2 job openings |
| 5 | Biodesix Developer of diagnostics assays for the detection of cancer | $200M | 42 mo ago | 217 217 → 360 (+66%) | 2005 | — | 226 patents Molecular diagnostic tests for cancer, infectious diseases, and prognostic biomarkers using proteomics and AI | — |
| 6 | OnKure Therapeutics Developer of epigenetic therapies for the treatment of cancer. | $195M | 20 mo ago | 35 | 2011 | Tony Piscopio Co-founder | — | 2 job openings |
| 7 | Rezolute Developing transformative therapies for rare diseases, focusing on hyperinsulinism (HI) | $191M | 68 mo ago | 51 51 → 73 (+43%) | 2012 | Nevan Elam Co-Founder & CEO | 89 patents Therapeutic antibodies targeting insulin receptor and plasma kallikrein inhibitor drugs. | — |
| 8 | Evolutionary Genomics Developer of genes for pest and disease resistance in plants | $176M | 49 mo ago | 2 | 1990 | Steve Warnecke CEO | 75 patents Genetically engineered crops for disease resistance, drought/salt tolerance, and yield improvement | — |
| 9 | Enliven Therapeutics Developer of drugs for solid tumours and blood cancers | $140M | 26 mo ago | 27 | 2019 | Anish Patel Co-Founder | — | — |
| 10 | NeuroMark Genomics Developer of a system for chronic rhinitis treatment via radiofrequency. | $110M | 4 mo ago | — | 2018 | David Townley Co-Founder & CTO | — | — |
| 11 | Foresight Diagnostics Developer of minimally-invasive liquid biopsy test for the detection of cancer | $104M | 22 mo ago | 35 | 2020 | Ash Alizadeh Co-Founder | — | — |
| 12 | BioIntelliSense Developer of medical-grade wearable devices and data services for patient monitoring 50Funding top 21%Moat top 21%Patents top 25%Innovation top 26% All 10 signals ▾Fundingtop 21% Moattop 21% Patentstop 25% Innovationtop 26% Producttop 35% Talenttop 38% Techbottom 49% Globalbottom 40% Marketbottom 36% Customersbottom 3% Funding: Raised $82.0M across 4 rounds · 4 rounds over 8 yrs (0.5/yr) Moat: Editorial + unicorn rating 8/10 · IP moat: 47 patents rank vs industry peers · Fliar Intelligence Index 50/100 | $82M | 6 mo ago | 26 | 2018 | James Mault Co-Founder&CEO | 47 patents Wearable multi-parameter physiological monitoring and biosensing devices | — |
| 13 | TriSalus Life Sciences Developer of drug delivery devices to treat cancers | $72M | 13 mo ago | 100 100 → 128 (+28%) | 2009 | Mary Szela CEO and President | 113 patents Patents concentrated in chemistry & materials | — |
| 14 | PharmaJet Provider of needle-free injection technology | $59M | 31 mo ago | 15 15 → 32 (+113%) | 2005 | — | 108 patents Jet injection devices for needle‑free drug delivery and precise dose control | 2 partnerships |
| 15 | VitriVax Developer of thermostable vaccines 37Funding top 23%Moat top 37%Patents top 42%Innovation top 48% All 6 signals ▾Fundingtop 23% Moattop 37% Patentstop 42% Innovationtop 48% Marketbottom 36% Globalbottom 36% Funding: Raised $55.5M across 5 rounds · 5 rounds over 6 yrs (0.8/yr) Moat: Editorial + unicorn rating 4/10 · IP moat: 7 patents rank vs industry peers · Fliar Intelligence Index 37/100 | $56M | 7 mo ago | 24 | 2014 | — | 7 patents Stable nucleic‑acid formulations and advanced chemical vapor deposition coating technologies | 1 job opening |
| 16 | Remedy Robotics Developer of endovascular robots | $35M | 8 mo ago | 12 12 → 21 (+75%) | 2020 | — | 51 patents Robotic navigation and imaging systems for endovascular catheter procedures | — |
| 17 | Viridian Therapeutics Developer of medicines for patients with serious and rare diseases | $34M | 1 mo ago | 94 | 2007 | — | — | — |
| 18 | Synergy Spine Solutions Developer of an artificial cervical disc for degenerative disc disease | $30M | 17 mo ago | 10 | 2005 | Josh Butters CEO | — | 3 launchs |
| 19 | Point Designs Provider of prosthetic fingers and partial hand prostheses 48Moat top 32%Innovation top 33%Funding top 35%Growth top 35% All 9 signals ▾Moattop 32% Innovationtop 33% Fundingtop 35% Growthtop 35% Patentstop 38% Talenttop 45% Techbottom 40% Globalbottom 31% Marketbottom 22% Moat: Editorial + unicorn rating 4/10 · IP moat: 22 patents Innovation: 22 patents (top 49% of patent-holders) · 17 filings since 2022 vs 5 in 2017-21 rank vs industry peers · Fliar Intelligence Index 48/100 | $27M | 14 mo ago | — | 2016 | Stephen Huddle Co-Founder | 22 patents Powered prosthetic hand components and actuation mechanisms for finger and thumb movement | — |
| 20 | Think Bioscience Provider of synthetic biology platform to develop small-molecule therapeutics 22Funding top 30%Talent top 38%Moat top 39%Global bottom 39% All 6 signals ▾Fundingtop 30% Talenttop 38% Moattop 39% Globalbottom 39% Techbottom 30% Marketbottom 28% Funding: Raised $26.0M across 4 rounds · 4 rounds over 6 yrs (0.7/yr) Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 22/100 | $26M | 4 mo ago | 21 21 → 31 (+48%) | 2019 | Jerome Fox Co-Founder & CEO | — | — |
| 21 | Arpeggio Provider of drug discovery platform for the treatment of cancer 24Funding top 27%Moat top 31%Talent top 38%Global bottom 37% All 6 signals ▾Fundingtop 27% Moattop 31% Talenttop 38% Globalbottom 37% Marketbottom 25% Newsbottom 22% Funding: Raised $25.4M across 5 rounds · 5 rounds over 7 yrs (0.7/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 24/100 | $25M | 7 mo ago | 8 | 2017 | Laura Norris Co-Founder | — | — |
| 22 | EvoEndo Developer of a medical device for un-sedated pediatric endoscopy | $21M | 22 mo ago | 17 | 2017 | Joel Friedlander Co-Founder | 22 patents Advanced flexible endoscopic systems with precise fluid, electrical, and steering control | — |
| 23 | Ambrosia Biosciences Developer of small molecule-based therapies for metabolic disorders | $16M | 2 mo ago | — | 2024 | Nick Traggis Founder & CEO | — | — |
| 24 | OncoVerity Developer of therapeutics for the treatment of cancer | $14M | 18 mo ago | — | 2022 | Max Colao CEO | — | — |
| 25 | Securisyn Developer of airway management system for ventilated patients | $11M | 10 mo ago | 10 | 2011 | Arthur Kanowitz Co-Founder & CEO | — | — |
| 26 | Exum Provider of tools and instruments for research 8Funding top 45%Tech top 45%Growth bottom 42%Global bottom 32% All 7 signals ▾Fundingtop 45% Techtop 45% Growthbottom 42% Globalbottom 32% Moatbottom 22% Marketbottom 16% Fin. healthbottom 8% Funding: Raised $9.9M across 8 rounds · 8 rounds over 7 yrs (1.1/yr) Tech: 23 technologies across 5/8 capability areas · Cloud: Cloudflare rank vs industry peers · Fliar Intelligence Index 8/100 | $10M | 6 mo ago | 15 | 2017 | — | — | 1 launch |
| 27 | Armis Biopharma Developer of prophylactic therapy for MDR-surgical site infections | $9M | 11 mo ago | 10 | 2017 | — | 49 patents Patents concentrated in health & consumer products | — |
| 28 | MuscleSound Point-of-care software for malnutrition assessment and improved patient care 14Moat top 25%Innovation top 46%Patents top 48%Product top 48% All 9 signals ▾Moattop 25% Innovationtop 46% Patentstop 48% Producttop 48% Fundingtop 49% Talentbottom 49% Globalbottom 37% Techbottom 21% Marketbottom 20% Moat: Editorial + unicorn rating 6/10 · IP moat: 34 patents Innovation: 34 patents (top 39% of patent-holders) · 11 filings since 2022 vs 16 in 2017-21 rank vs industry peers · Fliar Intelligence Index 14/100 | $8M | 7 mo ago | 6 | 2011 | Stephen Kurtz Chairman & CEO | 34 patents Non‑invasive muscle metabolic and architectural assessment for fitness and medical monitoring | — |
| 29 | KromaTiD Provider of molecular and genetic tests for detection of disease-causing mutations | $7M | 11 mo ago | 31 | 2007 | — | 12 patents Cytogenetic kits and methods for chromosome stability and genotoxicity assessment | 1 internship |
| 30 | SiVEC Biotechnologies Revolutionizing therapeutics with targeted live biotherapeutic delivery platform for advanced solutions | $7M | 9 mo ago | 5 | 2016 | Lyndsey Linke Co-Founder & CEO | 37 patents Bacterial vector platforms for intracellular delivery of antibodies, proteins, and therapeutic mRNA | — |
| 31 | Liberate Medical Developing respiratory muscle stimulator technology to liberate patients from mechanical ventilation 9Funding top 38%Moat top 48%Global bottom 32%Market bottom 27% All 5 signals ▾Fundingtop 38% Moattop 48% Globalbottom 32% Marketbottom 27% Techbottom 24% Funding: Raised $6.8M across 6 rounds · 6 rounds over 10 yrs (0.6/yr) Moat: Editorial + unicorn rating 5/10 · 9 curated direct competitors tracked rank vs industry peers · Fliar Intelligence Index 9/100 | $7M | 10 mo ago | 10 | 2013 | — | — | — |
| 32 | Rock Immune Developer of immunotoxins for cancer therapy | $7M | 15 mo ago | — | 2020 | Zhirui Wang Founder | — | — |
| 33 | Crestone Pharma Manufacturer of small molecule drugs for infectious diseases | $7M | 16 mo ago | 8 | 2015 | — | — | — |
| 34 | Nice Recovery Systems Developer of a cold compression therapy device | $6M | 21 mo ago | 10 | 2012 | Michael Ross Founder | — | 1 launch |
| 35 | Photonpharma Provider of antigen presentation technology | $6M | 21 mo ago | 3 | 2019 | Amanda Guth Co-Founder & CSO | — | — |
| 36 | RheumaGen Developer of therapeutics for auto-immune diseases | $5M | 17 mo ago | 4 | 2019 | Richard Freed Co-Founder & CEO | — | — |
| 37 | Pluto Biosciences Cloud-based research data management tool for scientists | $5M | 13 mo ago | 9 | 2020 | Rani Powers Founder & CEO | — | 1 launch |
| 38 | FluoroFinder Design and search tool to find the best flow cytometry products for the panel | $5M | 12 mo ago | 12 | 2008 | John Allen CEO | — | — |
| 39 | Circa Scientific Advanced esophageal temperature monitoring systems for OR and EP lab procedures | $4M | 21 mo ago | 15 | 2009 | — | 5 patents Epicardial cardiac ablation instrument ports and transseptal crossing devices for heart procedures. | 1 job opening · 1 launch |
| 40 | HeartHero Developing next-generation AEDs to improve survival rates from cardiac arrest | $4M | 11 mo ago | 6 | 2016 | — | 35 patents Advanced AED devices integrating synchronized cardioversion, drug delivery, and adaptive power management | — |
| 41 | VitroBioPharma Biologics company developing cell therapies for autoimmune diseases and inflammatory disorders | $4M | 12 mo ago | 10 | 1986 | — | — | — |
| 42 | GelSana Developer of novel hydrogels for wound healing | $4M | 11 mo ago | 2 | 2020 | Melissa Krebs Founder & CEO | — | 1 partnership · 1 award |
| 43 | Orbit Genomics Developer of cancer diagnostics and companion diagnostics for drugs in development | $4M | 14 mo ago | 6 | 2016 | Dede Willis Co-Founder & CEO | 15 patents Microsatellite genotyping and sample classification tools for genomic analysis | — |
| 44 | Fischer Medical Technologies Innovating diagnostic imaging for early and accurate breast cancer detection | $4M | 15 mo ago | 5 | 2006 | Morgan Nields President & CEO | — | — |
| 45 | AmideBio Peptide therapeutics innovator targeting metabolic diseases with custom synthesis services | $3M | 21 mo ago | 8 | 2009 | — | 49 patents Glucose‑responsive insulin and glucagon peptide therapeutics for diabetes management | — |
| 46 | Z biotech Glycomics solutions provider advancing research with innovative glycan microarray technology | $2M | 10 mo ago | 6 | 2013 | — | 109 patents Closed-system cryopreservation devices with integrated tracking and microbial feed production technologies. | — |
| 47 | Cime Therapeutics A biotechnology company focused on advancing drug discovery through a chemistry-first platform | $2M | 14 mo ago | — | 2024 | James Brewster Co-Founder & CEO | — | — |
| 48 | Sachi Bioworks Developer of an integrative bioinformatics platform for drug discovery using AI | $2M | 14 mo ago | 5 | 2020 | Anushree Chatterjee Co-Founder & CEO | — | 1 launch |
| 49 | Neurexis Therapeutics Developer of therapeutic peptide for neuroprotective effect | $605K | 10 mo ago | 3 | 2020 | — | — | 1 launch |
| 50 | Black Dog LED Manufacturer of LED grow lights for commercial, research, and home growing. | $250K | 9 mo ago | 6 | 2010 | Corey Drew Founder & Owner | — | — |
Top 12 Life Sciences companies in Colorado
#1
Enveda 🦄Series D · Boulder, Colorado · founded 2019$504.8Mraised▾
AI-based platform to decipher the chemistry of nature and develop new medicines. It employs advanced computational methods, high throughput automation, and metabolomics to identify potential treatments for various diseases. It leverages chemical knowledge of nature to accelerate drug discovery and development.
- Sep 2025Series D$150M
- Feb 2025Series C—
- Nov 2024Series C$130M
- Jun 2024Series B$55M
#2
Series C · Boulder, Colorado · founded 2018$110.2Mraised▾
Developer of a system for chronic rhinitis treatment via radiofrequency. The system uses low-power energy to disrupt posterior nasal nerves. It is designed as a minimally invasive solution. The technology includes a flexible shaft and leaflets for precise treatment.
- Feb 2026Series C$74.3M
- Dec 2024Series B—
- Jan 2021Series B$25M
- Jul 2020Grant (prize money)—
#3
Public · Boulder, Colorado · founded 2007 · 94 employees$34.5Mraised▾
Developer of medicines for patients with serious and rare diseases. The company is advancing a novel portfolio of neonatal Fc receptor (FcRn) inhibitors, VRDN-006 and VRDN-008, which has the potential to be developed in multiple autoimmune diseases.
- May 2026Post IPO$20M
- Feb 2015Series A$8.5M
- Sep 2010Series A$6M
#4
Series C · Denver, Colorado · founded 2018 · 26 employees$82Mraised▾
Developer of medical-grade wearable devices and data services for patient monitoring. it provides BioButton a rechargeable, multi-parameter wearable that captures vital signssuch as heart rate, respiratory rate, and skin temperature. It is integrated with data platforms BioCloud that provides advanced analytics and algorithmic notifications to support actionable triage and workflow efficiency and BioDashboard that Enables exception-based management for more proactive clinical decision-making.
- Dec 2025Series C$58.1M
- Jul 2021Series B$45M
- Aug 2020Series B$12M
- Dec 2018Series B$25M
#5
Series B · Boulder, Colorado · founded 2024$16Mraised▾
Developer of small molecule-based therapies for metabolic disorders. It offers an enzyme technology platform that converts obesity-promoting sugars into minimal-calorie rare sugars to treat obesity.
- Mar 2026Series B$100M
- Jul 2024Series A$16M
#6
Series A · Boulder, Colorado · founded 2019 · 21 employees$26Mraised▾
Provider of synthetic biology platform to develop small-molecule therapeutics. The company's platform combines applied microbiology, enzymology, and data science to develop medicines against difficult-to-drug proteins.
- Jan 2026Series A$55M
- May 2024Seed$6M
- Aug 2022Seed$17M
- Dec 2020Grant (prize money)$255.9K
#7
Series B · Boulder, Colorado · founded 2014 · 24 employees$55.5Mraised▾
Developer of thermostable vaccines and vaccine formulations. It is using a proprietary platform technology named a single shot, prime + boost microparticle vaccine platform and developed at the University of Colorado. The platform uses nanoparticles of antigen and adjuvant in an amorphous disaccharide glass matrix, which improves the stability and solubility of the product. The company is using the platform to develop thermostable vaccines of Anthrax, Botulinum toxin, Ebola glycoprotein, and HPV16 L1 capsomere.
- Oct 2025Series B$17.2M
- Jun 2025Series B$29.4M
- Apr 2025Grant (prize money)$5M
- Dec 2024Grant (prize money)$3.6M
#8
Series B · Boulder, Colorado · founded 2017 · 8 employees$25.4Mraised▾
Provider of drug discovery platform for the treatment of cancer. The company uses DNA sequencing and CRISPR-based screening technology to identify therapeutic targets and biomarkers to treat cancer. The company is developing drug candidates for Sarcomas, Lung Adenocarcinoma, and autoimmune diseases.
- Nov 2025Series B$20M
- Mar 2025Series A$4M
- Aug 2022Series A$20.2M
- Jan 2020Seed$3.2M
#9
Series A · Denver, Colorado · founded 2020 · 12 employees$35Mraised▾
Developer of endovascular robots. It offers solutions for doctors to conduct vascular interventions like placing stents in patients. The robots can be remotely operated.
- Oct 2025Series A$35M
#10
Series A · Denver, Colorado · founded 2017 · 15 employees$9.9Mraised▾
Provider of tools and instruments for research. The lead instrument, The Massbox, is the first Laser Ablation Laser Ionization Time of Flight Mass Spectrometer (LALI-TOF-MS) instrument on the market, capable of analyzing any sample, increasing the speed of development and discovery.
- Dec 2025Series A$120K
- Apr 2025Series A$1.1M
- Jul 2024Series A$1.5M
- May 2023Series A$6M
#11
Public · Westminster, Colorado · founded 2009 · 100 employees$72.3Mraised▾
TriSalus Life Sciences is involved in developing drug delivery devices to treat cancers. They have developed a technology platform, Pressure-Enabled Drug Delivery (PEDD), which is designed to improve the distribution and penetration of therapy in solid tumors.
- Apr 2025Post IPO$22M
- Dec 2024Post IPO$1000K
- Oct 2022Post IPO$15.3M
- Sep 2021Post IPO$23.5M
#12
Public · Longmont, Colorado · founded 2011 · 35 employees$195.2Mraised▾
Developer of epigenetic therapies for the treatment of cancer. It's lead drug ONK179, an HDAC 6 inhibitor which is being developed for the treatment of hematological and solid tumor cancers and ONK102 has reduced the growth rate of tumours when dosed by itself or in combination with other targeted therapies.
- Oct 2024Series C$65M
- Mar 2023Series C$54M
- Mar 2021Series B$56.6M
- Sep 2020Series A$1.5M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Life Sciences coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Biotechnology in Colorado is moving
A read on the academic research around Biotechnology in Colorado — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 90 papers.
Colorado State University leads Colorado's biotechnology research (90 papers, stance +0.50).
- Colorado State University32
- University of Colorado Anschutz Medical Campus29
- University of Colorado Denver17
- University of Colorado Boulder17
- Children\'s Hospital Colorado7
- Gene6
- RNA polymerase II5
- Messenger RNA4
- Polymerase4
- Transcription (linguistics)4
- Transcriptome1→3
- Gene2
- Gut flora2
- Self-healing hydrogels1
- In vivo1
- Biophysics1