Best Life Sciences Companies in Indiana, United States
The 197 best Life Sciences companies in Indiana, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Theravance Biopharma.
Our analysis of 164 Life Sciences companies
$34.7b in tracked funding; 83% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Life Sciences companies in Indiana
| # | Company | Disclosed funding | Last round | Employees | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|
| 1 | Theravance Biopharma Developer of therapeutics for inflammatory and immunological diseases | $610M | 90 mo ago | 99 99 → 166 (+68%) | Rick Winningham CEO | — | 1,587 patents Small‑molecule JAK kinase inhibitors and CNS therapeutic agents (ampreloxetine). | — |
| 2 | MBX Biosciences Developer of drugs for the treatment of rare endocrine diseases | $216M | 22 mo ago | 11 | Kent Hawryluk President & CEO | WordPressMySQLPHP+22 | — | 1 partnership |
| 3 | Greenlight Guru Developer of quality management system software for the medical device industry | $121M | 60 mo ago | 154 154 → 139 (-10%) | Ed Holmes CEO | HubSpot CMS HubSentryApple iCloud Mail+29 | — | — |
| 4 | On Target Laboratories Developer of molecular imaging agents for cancer surgery | $116M | 31 mo ago | 23 | Phil Low Founder & Chief Science Officer | WordPressApple iCloud MailMicrosoft 365+21 | 123 patents Targeted fluorescent and photodynamic dyes for cancer imaging and therapy | — |
| 5 | Endocyte Innovative medicines company reimagining medicine to improve and extend people’s lives | $108M | 147 mo ago | 220 | — | — | 641 patents Targeted cancer therapies: CAR‑T cell platforms, PSMA‑based conjugates, and PET imaging agents. | — |
| 6 | SpectronRx Provider of therapeutic and diagnostic isotope solutions 45Funding top 21%Growth top 28%Moat top 45%News top 46% All 11 signals ▾Fundingtop 21% Growthtop 28% Moattop 45% Newstop 46% Markettop 47% Talentbottom 49% Patentsbottom 41% Techbottom 37% Globalbottom 35% Partnersbottom 35% Innovationbottom 23% Funding: Raised $85.0M across 1 rounds · 1 rounds over 1 yrs (1.0/yr) Growth: Web rank 50,000,000 → 10,000,000 YoY · Fresh capital in last 24 mo rank vs industry peers · Fliar Intelligence Index 45/100 | $85M | 2 mo ago | 93 | John Zehner CEO | WordPressMySQLPHP+14 | 2 patents Radium‑226 extraction from phosphogypsum waste streams | — |
| 7 | Alios BioPharma Developer of antiviral therapies to treat infectious diseases | $71M | 145 mo ago | 49 | — | — | 601 patents Antiviral nucleoside analogs and modified oligonucleotides for viral infection treatment | — |
| 8 | Ipierian Developer of novel therapies for neurodegenerative diseases | $70M | 153 mo ago | 27 | Nancy Stagliano CEO | — | 119 patents Therapeutic antibodies and methods targeting tau protein in neurodegenerative diseases | — |
| 9 | NICO Developer of technology for the field of neurological corridor surgery | $62M | 44 mo ago | 49 | — | WordPressMySQLPHP+17 | 293 patents Minimally invasive surgical access devices and illumination-enabled instrument cannulas | — |
| 10 | AZI Developer of radiopharmaceuticals for imaging purposes | $58M | 97 mo ago | 4 | Gregory Brooksby Co-Founder & CEO | — | — | — |
| 11 | Biosynthetic Technologies Producer of bio-based green oils | $52M | 85 mo ago | 14 14 → 11 (-21%) | Mark Miller CEO | WordPress Block EditorWordPressMySQL+28 | 198 patents Synthetic estolide-based lubricants and base oils with enhanced oxidative stability | — |
| 12 | OrthoPediatrics Developer of orthopedic devices for children | $52M | 84 mo ago | 123 | Mark Throdahl President & CEO | WordPressMySQLPHP+26 | 212 patents Spinal orthopedic surgical instrumentation and implantable bone fixation devices | 1 launch · 1 partnership |
| 13 | Scioto Biosciences Developer of therapies for diabetes, neurological disorders, gastrointestinal and others using probiotics | $34M | 60 mo ago | 10 | Jim Schulz Co-Founder & CFO | — | — | — |
| 14 | Eons Provider of nutritional supplements for multiple ailments | $32M | 231 mo ago | 30 | Jeffrey Taylor Founder & CEO | Cart FunctionalityShopifySentry+33 | — | — |
| 15 | WishBone Medical Developer of devices for children suffering from orthopedic disorders | $30M | 42 mo ago | 62 | — | WordPressMySQLPHP+20 | — | — |
| 16 | Novosteo Developer of drug targeting technology for bone fracture repair | $27M | 50 mo ago | 18 | — | — | — | — |
| 17 | Chondrial Therapeutics Biotechnology firm developing treatments for rare diseases using intracellular delivery platform | $23M | 112 mo ago | 21 | Mark Payne Co-Founder | — | — | — |
| 18 | Nextremity Solutions Developer of extremity musculoskeletal orthopedic products | $22M | 133 mo ago | 25 | Lon Weiner Co-Founder & Director | AMPGoogle Font APICloudflare Browser Insights+5 | 258 patents Orthopedic surgical tools for bone fixation, alignment, and instrument torque control | — |
| 19 | FAST BioMedical Fluorescent in-vivo markers to measure plasma volume and mGFR | $22M | 90 mo ago | 2 | — | — | 26 patents Quantitative biomedical diagnostics using fluorescent markers and blood/renal volume measurement. | — |
| 20 | eradivir Developer of immunotherapies for the treatment of infectious diseases 22Funding top 32%Talent top 38%Growth top 45%Moat bottom 38% All 7 signals ▾Fundingtop 32% Talenttop 38% Growthtop 45% Moatbottom 38% Globalbottom 29% Techbottom 24% Marketbottom 23% Funding: Raised $20.0M across 5 rounds · 5 rounds over 6 yrs (0.8/yr) Talent: 2 named leaders on record · 2 C-suite/founder profiles curated rank vs industry peers · Fliar Intelligence Index 22/100 | $20M | 8 mo ago | 6 | Martin Low Co-Founder & CEO | WordPressMySQLPHP+11 | — | — |
| 21 | Esanex Developing anticancer heat shock protein (HSP) inhibitors | $19M | 110 mo ago | — | Steven Hall CEO & President | — | 31 patents Novel heterocyclic benzamide compounds for anticancer combination therapies | — |
| 22 | Nanovis Manufacturer of nano-technology based spinal implants | $17M | 76 mo ago | 12 12 → 28 (+133%) | — | — | 75 patents Nanostructured calcium‑phosphate coatings for antimicrobial medical device surfaces via pulsed electrodeposition | — |
| 23 | Recovery Force Wearable massage compression sleeves and wraps | $16M | 67 mo ago | 15 | — | — | 59 patents Wearable medical compression devices for deep vein thrombosis prevention and therapy | — |
| 24 | Gate Neurosciences Developer of therapies for a broad range of neuropsychiatric and cognitive disorders | $16M | 54 mo ago | 12 | Michael McCully Co-Founder & CEO | — | — | — |
| 25 | Marcadia Biotech Developer of therapeutic products for diabetes and obesity | $16M | 229 mo ago | 1 | — | — | — | — |
| 26 | BioPoly Orthopedic devices in the sports medicine | $14M | 16 mo ago | 10 | Herb Schwartz President & CEO | WordPressMySQLPHP+8 | 47 patents Orthopedic joint replacement implants for shoulder, elbow, and toe surgeries | — |
| 27 | PURSPEC Manufacturer of high-end portable mass spectrometry instruments | $14M | 25 mo ago | — | Zheng Ouyang Founder | — | — | — |
| 28 | Indigo BioAutomation Automated data analysis, management and integration solutions | $12M | 145 mo ago | 27 | — | WordPressApple iCloud MailMicrosoft 365+25 | — | — |
| 29 | Positron Provider of PET and PET‑CT medical imaging systems | $11M | 14 mo ago | 15 | — | — | 10 patents Multi-axis VR motion control systems and avalanche photodiode pixel sensor technologies | — |
| 30 | GeniPhys Developer of collagen polymers for tissue regeneration | $10M | 4 mo ago | 4 | — | — | 18 patents Collagen-based biologic fillers for tissue regeneration and high-strength matrix scaffolds. | — |
| 31 | Toralgen Developer of oral formulations of anti-diabetic drugs | $10M | 66 mo ago | 9 | — | — | — | — |
| 32 | SonarMed Global healthcare technology company specializing in medical devices and therapies | $10M | 37 mo ago | 6 | — | — | 38 patents Acoustic sensing for catheter navigation and respiratory device monitoring in medical applications. | — |
| 33 | Vascugen Regenerative medicine company developing cell therapies for vascular diseases and tissue engineering | $10M | 69 mo ago | 10 | Carter Cliff Founder & CEO | — | 2 patents Engineered vasculogenic cell therapies for treating perfusion and vascular disorders. | — |
| 34 | Tymora Analytical Provider of laboratory technologies for protein research | $9M | 17 mo ago | 3 | — | Cart FunctionalityWooCommerceWordPress+21 | 13 patents Extracellular vesicle isolation and cancer biomarker liquid‑biopsy diagnostics | 1 launch · 2 partnerships |
| 35 | Apexian Pharma Developer of small molecule therapeutics for the treatment of cancer | $8M | 57 mo ago | 4 | — | — | — | — |
| 36 | Amplified Sciences Developer of in-vitro diagnostic test for the detection of debilitating diseases across oncology and chronic… | $6M | 10 mo ago | 6 | Vincent Jo Davisson Founder and CSO | — | — | 1 internship |
| 37 | Adipo Therapeutics Developer of therapeutic solutions for the treatment of obesity & diabetes | $4M | 19 mo ago | 3 | Meng Deng Founder | WordPressMySQLPHP+15 | — | — |
| 38 | Early Is Good Developer of multi-omic platform for biomarker detection to transform healthcare | $4M | 20 mo ago | 5 | Asel Liyanage Co-Founder | — | — | — |
| 39 | HB Therapeutics Developer of therapeutic drugs designed to make anti-cancer and anti-aging medicines | $4M | 47 mo ago | — | Anita Bellail Founder | — | 1,876 patents Targeted protein degradation (PROTACs) and exosome-based therapies for oncology and neurodegeneration | — |
| 40 | Rescue Biomedical Developer of a device to detect an opioid overdose | $3M | 43 mo ago | — | Hyowon Lee CEO | — | — | — |
| 41 | Akina Research products and services for controlled release, medicinal delivery, biomedical applications | $3M | 33 mo ago | 10 | — | — | 49 patents Biodegradable polymer drug delivery systems for therapeutic proteins and toxins | — |
| 42 | Zorion Medical Developing absorbable vascular scaffolds for peripheral artery disease treatment | $2M | 40 mo ago | 5 | — | — | — | — |
| 43 | OpalGenix Developer of a genetic test for precision opioid and pain management | $2M | 12 mo ago | 2 | Senthilkumar Sadhasivam Founder | — | — | — |
| 44 | Novilytic Developer of molecular recognition system to detect the quality of medicines | $2M | 6 mo ago | 8 | Paul Dreier Chief Executive Officer | — | 30 patents Proteoform-specific analytical assays for recombinant therapeutic protein characterization | 1 partnership |
| 45 | GrannuS Developer of small molecule inhibitors for the treatment of oncology | $1M | 31 mo ago | 2 | Sanket Mishra Co-Founder | — | 39 patents Integrated hydrogen, power, and fertilizer production using carbon capture and fuel‑cell by‑products | — |
| 46 | NERx BioSciences Discovery and development of targeted therapeutics for cancer | $1M | 22 mo ago | 2 | — | — | — | — |
| 47 | Lyowave Developer of high-frequency microwave heating technology for pharmaceutical freeze-drying | $604K | 12 mo ago | — | Dimitrios Peroulis Co-Founder | — | — | — |
| 48 | Compact Medical Solutions Developer of breathing device | $235K | 9 mo ago | — | Gustavo Amorim Co-Founder | — | — | — |
| 49 | BioReact Platform offering AI bioprocess parameter optimization software | $120K | 4 mo ago | — | Joanna Lipinski Co-Founder & CTO | Cart FunctionalitySquarespace CommerceSquarespace+13 | — | — |
| 50 | Insignum AgTech Developer of plant signaling technology for optimized crop management decisions | $100K | 9 mo ago | 2 | Kyle Mohler Founder & CEO | — | 7 patents Genetically engineered plants for rapid detection of pathogenic diseases in agriculture | — |
Top 12 Life Sciences companies in Indiana
#1
Series C · Indianapolis, Indiana · founded 2004 · 93 employees$85Mraised▾
SpectronRx is a provider of therapeutic and diagnostic isotope solutions. It provides radionuclides and custom theranostic contract manufacturing like monoclonal antibody labelling, peptides, radiolabeling of molecules and chemical entities, and aptamers.
- Apr 2026Series C$85M
#2
Series A · Zionsville, Indiana · founded 2014 · 4 employees$10.5Mraised▾
Developer of collagen polymers for tissue regeneration. It offers Collymer a polymerizable scaffold-forming collagen that supports tissue restoration and regeneration. It is used in cartilage replacement, vascular grafts, and heart valve replacement, and others.
- Jan 2026Series A$3M
- Oct 2024Grant (prize money)$500K
- Mar 2023Series A$6M
- Nov 2022Series A$4.5M
#3
Series A · West Lafayette, Indiana · founded 2020 · 6 employees$20Mraised▾
Developer of immunotherapies for the treatment of infectious diseases. The company has developed a proprietary technology platform miniBIT to design targeted immunotherapies for multiple infectious diseases. The advanced product of the company's pipeline is a targeted therapy for influenza virus infections that eliminates all free virus and virus-infected cells.
- Oct 2025Series A$10M
- Sep 2024Grant (prize money)$1M
- Sep 2024Series A$10.2M
- Feb 2021Grant (prize money)$256K
#4
Public · Carmel, Indiana · founded 2018 · 11 employees$215.6Mraised▾
MBX Biosciences is a developer of drugs for the treatment of rare endocrine diseases. It has developed endocrine drugs including Forteo and Humalog for the treatment of rare diseases. It uses use peptide hormones to regulate many physiological functions including growth, energy utilization, metabolism, gastrointestinal function, and stress responses.
- Aug 2024Series C$63.5M
- Nov 2022Series B$115M
- Jul 2020Series A$34.6M
- 2019Seed$2.5M
#5
Seed · West Lafayette, Indiana · founded 2016 · 6 employees$5.6Mraised▾
Developer of in-vitro diagnostic test for the detection of debilitating diseases across oncology and chronic kidney disease. The company offers PanCystPro uses a proprietary platform to detect biomarker levels and activity in minute volumes of pancreatic cyst fluid for patients at higher risk for pancreatic cancer diagnosed with pancreatic cystic lesions.
- Aug 2025Seed$3M
- Mar 2025Grant (prize money)$454.9K
- Apr 2024Grant (prize money)$275K
- Mar 2024Grant (prize money)$274.8K
#6
Seed · West Lafayette, Indiana · founded 2021 · 8 employees$1.6Mraised▾
Developer of molecular recognition system to detect the quality of medicines. The company has developed a Proteometer that is capable of identifying and quantifying titer and relative aggregate content in crude culture filtrate. The Proteometer (Proteoform Meter) is a technology for drug development companies that provides near-real-time warnings on molecular structure changes.
- Dec 2025Seed$530.8K
- May 2022Seed$1.6M
- Jul 2021Grant (prize money)$1.4M
- Jun 2021Grant (prize money)$1.1M
#7
Series D · Fort Wayne, Indiana · founded 2007 · 10 employees$14.1Mraised▾
BioPoly engages in the research, design, and manufacture of orthopedic devices for use in the sports medicine, orthopedics, and spinal markets. It offers BioPoly RS Knee System, a femoral condyle partial resurfacing device that is implanted utilizing a reusable instrument kit; and BioPoly-RS Partial Resurfacing Knee Implant, a long term surgically invasive device for the replacement of focal osteochondral defects in the knee.
- Jan 2025Series D$1.1M
- Jan 2023Series D$300K
- Dec 2019Series D$2M
- Nov 2016Series D$1.7M
#8
Public · Fishers, Indiana · founded 1983 · 15 employees$10.8Mraised▾
Provider of PET and PET‑CT medical imaging systems. It offers Attrius PET a 2D cardiac PET scanner offering high‑resolution imaging and advanced coronary flow reserve software and NeuSight PET‑CT 64‑slice a hybrid PET‑CT scanner doe cardiac‑oncology applications.
- Mar 2025Post IPO$8M
- Nov 2012Post IPO$1.3M
- Mar 2009Post IPO$1.5M
#9
Funding Raised · Lafayette, Indiana · founded 2010 · 3 employees$8.6Mraised▾
Provider of laboratory technologies for protein research. The product line of the company includes pIMAGO and PolyMAC. pIMAGO is based on water-soluble, globular nanopolymers that specifically recognize phosphate groups, with reporting groups such as biotin and fluorophore that facilitate their detection. PolyMAC, on the other hand, recognizes phosphopeptides and is based on a metal-ion functionalized soluble nanopolymer.
- Jan 2025Grant (prize money)$290K
- Sep 2022Grant (prize money)$290K
- Aug 2021Grant (prize money)$310K
- Apr 2020Grant (prize money)$300K
#10
Funding Raised · Indianapolis, Indiana · founded 2020 · 2 employees$2.4Mraised▾
Developer of a genetic test for precision opioid and pain management. The GPS-Opioid technology is a pre-operative laboratory-developed test that has polygenetic and intelligent analytics for the prediction of opioid-related adverse effects, and severe surgical pain.
- May 2025Grant (prize money)$325.2K
- Feb 2025Grant (prize money)$374.4K
- Aug 2023Grant (prize money)$644.4K
- May 2023Grant (prize money)$325.2K
#11
Series C · West Lafayette, Indiana · founded 2010 · 23 employees$116.5Mraised▾
Developer of molecular imaging agents for cancer surgery. It offers molecular imaging technology-based fluorescent markers to illuminate cancer during surgery so cancerous tissue can be removed during surgical procedures.
- Nov 2023Series C$30M
- Mar 2021Series B$21M
- Mar 2018Series B$11.1M
- Nov 2017Series B$32.5M
#12
Seed · Indianapolis, Indiana · founded 2023$120Kraised▾
Platform offering AI bioprocess parameter optimization software. It helps researchers understand bioreactor conditions to enable cell thriving. It provides an AI that is trained on data points covering various cells. It analyzes, models, and optimizes crucial parameters such as temperature, pH, nutrient concentrations, media composition, and fermentation times.
- Feb 2026Seed—
- Sep 2024Seed$120K
- Seed$1.1M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Life Sciences coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Biotechnology in Indiana is moving
A read on the academic research around Biotechnology in Indiana — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 43 papers.
IUPUI, IU Bloomington, and IU School of Medicine lead Indiana's biotechnology research, focusing optimistically on bacterial biofilms, gene therapy, and RNA splicing mechanisms.
- Indiana University – Purdue University Indianapolis18
- Indiana University Bloomington16
- Indiana University School of Medicine14
- Indiana University7
- Indiana University Health6
- Transcription factor2
- Transcription (linguistics)2
- DNA-binding protein2
- Gene expression2
- DNA sequencing2
- Extracellular matrix2
- Gene expression2
- Decellularization1
- Keloid1
- Gene knockdown1
- Antibody2
- Wolbachia1
- Immunoprecipitation1
- Ankyrin repeat1
- Drosophila melanogaster1