Best Sustainability Tech Companies in Pennsylvania, United States
The 231 best Sustainability Tech companies in Pennsylvania, United States in 2026, ranked by funding and momentum. Funding, investors, founders, valuation, tech stack and live signals. Top: Inovio Pharmaceuticals.
Our analysis of 84 Sustainability Tech companies
$19.4b in tracked funding; 85% of the stack-profiled cohort runs cloud-native; funding activity peaked in 2025.
Ranked: Best Sustainability Tech companies in Pennsylvania
| # | Company | Disclosed funding | Last round | Employees | Founded | Founder | Tech stack | Patents & IP focus | Recent signals |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Inovio Pharmaceuticals Developer of vaccines for the treatment of cancer and infectious diseases | $495M | 66 mo ago | 275 275 → 199 (-28%) | 1983 | Joseph Kim Co-Founder & CEO | WordPressMySQLPHP+21 | 1,154 patents Therapeutic DNA vaccines and electroporation delivery systems for viral and cancer targets | — |
| 2 | Renmatix Technology developer for cellulosic sugar | $251M | 74 mo ago | 49 | 2007 | — | WordPressMySQLPHP+24 | 437 patents Production and application of nano-cellulose particles and cellulose-based composites. | — |
| 3 | VenatoRx US-based, clinical stage biotech developing beta-lactamase inhibitors for DR infections 50Funding top 19%Product top 25%Innovation top 34%Growth top 39% All 9 signals ▾Fundingtop 19% Producttop 25% Innovationtop 34% Growthtop 39% Moattop 39% Marketbottom 40% Globalbottom 37% Newsbottom 27% Techbottom 25% Funding: Raised $103M across 35 rounds · 35 rounds over 13 yrs (2.7/yr) Product: 8 distinct product lines · Company stage: Series C rank vs industry peers · Fliar Intelligence Index 50/100 | $103M | 12 mo ago | 80 | 2010 | — | WordPressMySQLPHP+9 | — | — |
| 4 | Tarsa Therapeutics Developer of oral treatment for postmenopausal osteoporosis | $79M | 106 mo ago | 2 | 2009 | — | — | — | — |
| 5 | Viridity Energy Demand side management by online software | $76M | 121 mo ago | 27 | 2008 | — | — | — | — |
| 6 | PURAGLOBE Provider of used oil recycling company | $76M | 46 mo ago | 277 | 1995 | Andreas Schuppel CEO & President | WebflowApple iCloud MailPreact+10 | — | — |
| 7 | Excision Developer of CRISPR-based therapies to cure viral infectious diseases | $71M | 64 mo ago | 48 | 2015 | Daniel Dornbusch CEO | BootstrapApache HTTP ServerjQuery+10 | — | — |
| 8 | Plextronics Developer of conductive polymers and inks for electronic printing | $59M | 152 mo ago | 31 | 2002 | — | — | 293 patents Conductive polymers for organic photovoltaics, OLEDs, capacitors, and device encapsulation | — |
| 9 | Latus Developer of gene therapy medicines for neurological diseases 35Funding top 26%Moat top 31%Talent bottom 49%Market bottom 40% All 5 signals ▾Fundingtop 26% Moattop 31% Talentbottom 49% Marketbottom 40% Globalbottom 36% Funding: Raised $54.0M across 2 rounds · 2 rounds over 2 yrs (1.0/yr) Moat: Editorial + unicorn rating 8/10 · Soonicorn rank vs industry peers · Fliar Intelligence Index 35/100 | $54M | 1 mo ago | — | 2022 | P Ghoroghchian CEO | — | — | — |
| 10 | RedZone Robotics Robotic and software solution for wastewater network monitoring | $53M | 124 mo ago | 76 | 1987 | Dave Petrosky Chief Executive Officer | WordPress Block EditorElementorWordPress+32 | 100 patents Robotic modular platforms for visual and sensor‑based inspection of underground infrastructure | — |
| 11 | Nucleonics Developing RNAi therapeutics for Hepatitis B and C, using eiRNA technology | $52M | 260 mo ago | — | 2001 | John Maraganore CEO | — | 46 patents RNAi-based antiviral therapeutics and gene‑silencing platforms for hepatitis viruses | — |
| 12 | ClimeCo Provider of environmental project development and management services | $50M | 50 mo ago | 59 59 → 93 (+58%) | 2011 | Bill Flederbach President and CEO | WordPressApple iCloud MailMicrosoft 365+36 | — | — |
| 13 | Auxilium Pharmaceuticals Developer of therapeutics and drug-device combinations for urology and sexual health | $43M | 271 mo ago | 484 | 1999 | — | — | — | — |
| 14 | Peptilogics Developer of antibiotics to target MDR bacteria 50Patents top 20%Funding top 23%Innovation top 24%Moat top 32% All 9 signals ▾Patentstop 20% Fundingtop 23% Innovationtop 24% Moattop 32% Talentbottom 49% Techbottom 48% Newsbottom 42% Globalbottom 42% Marketbottom 29% Patents: 83 patents matched (strict assignee match) · 67 filings since 2022 vs 16 in 2017-21 Funding: Raised $42.4M across 13 rounds · 13 rounds over 10 yrs (1.3/yr) rank vs industry peers · Fliar Intelligence Index 50/100 | $42M | 8 mo ago | 23 23 → 22 (-4%) | 2013 | Jonathan Steckbeck Founder | President | CEO | WordPressBugHerdMySQL+25 | 83 patents Antimicrobial peptide therapeutics and AI-driven peptide drug discovery platforms | — |
| 15 | Harrisburg Housing Authority Provider of housing solutions and programs | $42M | 5 mo ago | 37 | 2000 | — | Apple iCloud MailBootstrapModernizr+7 | — | 1 job opening |
| 16 | McKeesport Housing Authority Operator of federally assisted housing units and a voucher program | $26M | 6 mo ago | — | 2001 | — | WordPressMySQLPHP+12 | — | — |
| 17 | Evrys Bio Developer of broad-spectrum drugs that treat multiple viruses | $24M | 13 mo ago | 16 | 2012 | — | — | — | — |
| 18 | Sapient Industries Provider of AI-driven energy management system | $21M | 62 mo ago | 28 | 2018 | Sam Parks Co-Founder & Chief Product Officer | WebflowApple iCloud MailGoogle Workspace+15 | 16 patents Location-based advertising platforms and region-aware IoT analytics for targeted digital media | — |
| 19 | Protez Pharmaceuticals Develops antibiotics for hospital infections caused by drug-resistant bacteria | $21M | 249 mo ago | 6 | 2003 | — | — | — | — |
| 20 | InspectionGo SaaS-driven building inspection solutions for facility managers | $10M | 27 mo ago | 36 36 → 69 (+92%) | 2019 | Chad Hett Co-Founder | WordPressApple iCloud MailGoogle Workspace+36 | — | — |
| 21 | Powercast Provider of wireless power technologies, devices, development kits, and design services | $10M | 230 mo ago | 14 | 2003 | Joe Walton co-founder | WordPressMySQLPHP+28 | 263 patents Wireless RF power transfer and energy harvesting for battery‑less IoT devices | 2 launchs |
| 22 | kWantera Predictive analytics for Power seller and purchases of the wholesale energy market | $10M | 113 mo ago | 7 | 2006 | Mark DeSantis Co-Founder | — | — | — |
| 23 | Conservation Labs Provider of IoT-based water pipeline monitoring solutions | $10M | 27 mo ago | 19 | 2016 | Mark Kovscek Founder and CEO | WordPressMySQLPHP+23 | 51 patents Patents concentrated in transport & manufacturing processes | — |
| 24 | Versify Provider of compliance services | $9M | 122 mo ago | 11 | 2003 | — | WordPressMySQLPHP+21 | 21 patents Real-time monitoring and aggregation of distributed generators and demand‑response systems | 1 launch |
| 25 | Molecular Detection Molecular diagnostics company focused on rapid, accurate infectious disease detection | $8M | 156 mo ago | — | 2007 | Aryeh Gassel Co-Founder | — | 26 patents Molecular diagnostic kits for PCR-based detection of antibiotic‑resistant bacteria. | — |
| 26 | Mon Valley Initiative Provider of housing counseling, workforce development, and real estate development services | $7M | 140 mo ago | 76 | 1988 | — | Cart FunctionalitySquarespace CommerceSquarespace+24 | — | — |
| 27 | Encentiv Energy Online platform offering energy efficiency incentive solutions | $7M | 64 mo ago | 27 | 2009 | — | — | — | 3 launchs |
| 28 | Ocean Thermal Energy Corporation Developer of marine technologies based on OTEC and SWAC | $7M | 101 mo ago | 2 | 1988 | — | — | — | — |
| 29 | Crystalplex Develops alloy gradient quantum dots (QDs) for the Optoelectronics industry | $6M | 83 mo ago | 4 | 2003 | Matt Bootman CEO & President | — | 41 patents Nanocrystal quantum dot dispersion and stabilization for optoelectronic devices | — |
| 30 | Biomeme Developer of a smartphone-based DNA detection platform | $6M | 109 mo ago | 202 | 2013 | — | Tailwind CSSAmazon Web ServicesAstro+5 | 89 patents Portable point‑of‑care nucleic acid extraction, amplification, and detection devices for infectious diagnostics | — |
| 31 | KOKO Medical Developer of medical device to address postpartum hemorrhage of women | $6M | 4 mo ago | 10 | 2019 | Skott Greenhalgh Co-Founder & CEO | — | — | — |
| 32 | The Efficiency Network Provider of building energy efficiency management solutions | $6M | 123 mo ago | 29 29 → 59 (+103%) | 2012 | Rob Campbell Pe President and Co-Founder | SanityTailwind CSSEmotion+8 | — | 1 job opening |
| 33 | Boss Controls Energy management system with smart plugs | $5M | 93 mo ago | 15 | 2012 | — | — | — | — |
| 34 | UE LifeSciences Provider of a non-invasive breast cancer scanning device | $5M | 54 mo ago | 44 44 → 64 (+45%) | 2009 | Bhaumik Sanghvi Co-Founder & COO | Cart FunctionalityStrikinglyNginx+18 | 65 patents Capacitive tactile sensors for non‑invasive tissue property measurement and lesion mapping | — |
| 35 | Clean Robotics Manufacturer of a smart trash bin robot for sorting recyclables from landfill waste | $4M | 36 mo ago | 15 | 2015 | — | — | — | — |
| 36 | LIA Diagnostics Disposable paper pregnancy test kits | $4M | 91 mo ago | 6 | 2015 | Bethany Edwards Co-Founder | — | — | — |
| 37 | CeeLite Provider of the flat light emitting capacitor and LED lighting products | $4M | 221 mo ago | 90 | 2004 | — | — | 11 patents Electroluminescent lighting modules with constant‑brightness control and safety circuitry | — |
| 38 | Fischer Block Developer of power system management and sensor data analytics for smart grid | $4M | 93 mo ago | 3 | 2013 | — | — | 26 patents Predictive maintenance and condition monitoring for power and wind turbine assets | — |
| 39 | Airviz Device for indoor air quality monitoring | $3M | 103 mo ago | — | 2014 | Shweta Sarode Founder | — | 14 patents Low‑power indoor air‑quality sensing, ultrafine particle detection, and data analytics | — |
| 40 | Pearl Street Technologies Provider of grid planning solutions | $3M | 15 mo ago | 13 13 → 23 (+77%) | 2018 | David Bromberg Co-Founder & CEO | WordPressMySQLPHP+22 | — | — |
| 41 | Mission First Housing Developer and manager of affordable, equitable, safe, and sustainable homes | $2M | 176 mo ago | — | 1988 | — | WordPressPleskMySQL+17 | — | 1 partnership |
| 42 | CSI Provider of test kits for the detection of infectious diseases | $2M | 38 mo ago | 15 | 2019 | Gary Shope CEO | — | 79 patents Automotive damage inspection and repair using objective imaging and data analytics | — |
| 43 | Prescient Weather Provider of weather and climate risk management services for various industries | $2M | 64 mo ago | 4 | 2009 | Richard James Co-Founder | — | — | — |
| 44 | EnviroKure Biostimulants and biofertilizers improving crop yields and soil health | $2M | 67 mo ago | 22 | 2011 | — | — | 41 patents Production of biofertilizer and soil amendment compositions for enhanced plant nutrition. | — |
| 45 | INTAG Provider of recycling and nutrient delivery solutions for agribusinesses | $1M | 62 mo ago | 6 | 2016 | Bob Welsh CEO | — | — | — |
| 46 | Sustainable Composites Upcycler of leather waste into reusable materials | $1M | 21 mo ago | 8 | 2012 | Frank Fox Co-Founder | — | 7 patents High‑strength, tear‑resistant leather composites and dispersion aids for leather processing | — |
| 47 | Clarion Housing Provider of housing assistance and related programs for eligible individuals | $783K | 13 mo ago | — | 2008 | — | WordPress Block EditorWordPressMySQL+10 | — | — |
| 48 | Rego Provider of waste diversion operations automation and data management solutions | $270K | 27 mo ago | — | 2020 | Brandon Castagna Co-Founder | Wix eCommerceWixSentry+16 | — | — |
| 49 | Akeptus Provider of AI-based home automation systems for energy management | $150K | 23 mo ago | — | 2019 | Nana Wilberforce Founder & CEO | — | — | — |
Top 12 Sustainability Tech companies in Pennsylvania
#1
Series A · Philadelphia, Pennsylvania · founded 2022$54Mraised▾
Developer of gene therapy medicines for neurological diseases. The company leverages precision delivery through Adeno-Associated Virus to target specific cells and tissues, to improve the lives of patients suffering from various central nervous system disorders.
- May 2026Series A$97M
- May 2024Series A$54M
#2
Funding Raised · Harrisburg, Pennsylvania · founded 2000 · 37 employees$41.7Mraised▾
It is a housing organization located in Harrisburg, PA. They offer apartments and housing options through their Housing Choice Voucher Program. They administer public housing units and Section 8 vouchers in the city.
- Dec 2025Grant (prize money)$408.5K
- Nov 2025Grant (prize money)$441.1K
- Sep 2025Grant (prize money)$4.7M
- Aug 2025Grant (prize money)$2.2M
#3
Series B · Pittsburgh, Pennsylvania · founded 2013 · 23 employees$42.4Mraised▾
Peptilogics has developed antibiotics to target Multi-drug resistant bacteria. The company has developed eCAPS technology to produce novel antibiotics for drug-resistant bacteria. It acts by disrupting the bacterial membrane and inactivating it. It has shown effectiveness against the ESKAPE pathogens, both gram-positive and gram-negative, that cause the majority of resistant hospital-acquired infections.
- Oct 2025Series B$78M
- Jan 2025Grant (prize money)$3.3M
- Aug 2022Grant (prize money)$499.4K
- Sep 2021Grant (prize money)$698.7K
#4
Funding Raised · Mckeesport, Pennsylvania · founded 2001$26.2Mraised▾
Operator of federally assisted housing units and a voucher program. It provides housing options for low-income individuals and families. The organization owns and operates senior living communities, handicapped accessible housing, and neighborhood sites with town homes and single-family homes. It also manages a voucher program that assists individuals who reside in privately owned rental properties. Federal guidelines regarding income apply to these programs.
- Nov 2025Grant (prize money)$165K
- Aug 2025Grant (prize money)$165K
- Jun 2025Grant (prize money)$3.7M
- May 2025Grant (prize money)$2.6M
#5
Series C · Malvern, Pennsylvania · founded 2010 · 80 employees$102.7Mraised▾
VenatroRx is a US-based, clinical stage biotech developing beta-lactamase inhibitors for DR infections. The company focuses on beta-lactamase inhibitors that target penicillin binding proteins to overcome bacterial resistance to beta-lactam drugs. Their lead candidate, VNRX‐5133, is an intravenous beta‐lactamase inhibitor. VNRX‐5133 is designed to inhibit the four major classes of beta‐lactamase resistance enzymes, including metallo‐beta‐lactamases (MBL). VenatoRx plans to use the drug to inhibit bacterial resistance mechanisms, enabling a paired beta-lactam antibiotic to kill the microorganisms. The other candidate is VNRX‐7145, an orally bioavailable beta‐lactamase inhibitor that is in late preclinical testing. In Jul.2017, the company was awarded $9.4M from CARB-X (Combating Antibiotic-Resistant Bacteria Accelerator)
- May 2025Grant (prize money)$6.3M
- May 2025Grant (prize money)$3M
- Apr 2025Grant (prize money)$2M
- Feb 2025Grant (prize money)$7.4M
#6
Series B · Malvern, Pennsylvania · founded 2019 · 10 employees$6Mraised▾
Developer of medical device to address postpartum hemorrhage of women. It offers KOKO device, is a catheter-based technology to encourage uterine contractions while removing excess blood to stop postpartum hemorrhaging.
- Feb 2026Series B$8M
- Dec 2023Series A$6M
- Nov 2021Seed$2.5M
#7
Series A · Doylestown, Pennsylvania · founded 2012 · 16 employees$24.2Mraised▾
Developer of broad-spectrum drugs that treat multiple viruses. It offers antivirals target special human proteins, known as sirtuins, enhancing their natural ability to fight powerful infections which include hepatitis B virus and hepatitis C virus.
- Apr 2025Grant (prize money)$6.9M
- Jan 2025Grant (prize money)$2.2M
- Aug 2021Grant (prize money)$1.3M
- Aug 2016Grant (prize money)$2.3M
#8
Acquired · Pittsburgh, Pennsylvania · founded 2018 · 13 employees$2.8Mraised▾
Provider of grid planning solutions
- Mar 2025Grant (prize money)$1.3M
- Mar 2022Seed$2.8M
- Oct 2021Grant (prize money)$340K
- Apr 2020Grant (prize money)$749.9K
#9
Public · Plymouth Meeting, Pennsylvania · founded 1983 · 275 employees$495.2Mraised▾
Developer of vaccines for the treatment of cancer and infectious diseases. Its synthetic DNA vaccines, in combination with its proprietary electroporation delivery, are generating antibody and therapeutic T-cell responses. Inovio's broad pipeline includes immunotherapies to fight cancers of the cervix head and neck, prostate, breast, lung, and pancreas as well as to protect against and eliminate infectious diseases such as hepatitis, HIV, Ebola, and MERS.
- Dec 2020Grant (prize money)$37.6M
- Jun 2020Grant (prize money)$71M
- Apr 2020Grant (prize money)$6.9M
- Mar 2020Grant (prize money)$5M
#10
Funding Raised · Clarion, Pennsylvania · founded 2008$782.9Kraised▾
Provider of housing assistance and related programs for eligible individuals. It offers various housing options and support services to improve quality of life. The organization facilitates access to safe and affordable homes for elderly persons, families, and those with special needs. It also promotes self-sufficiency and homeownership through its programs.
- May 2025Grant (prize money)$102.5K
- Mar 2025Grant (prize money)$200.9K
- Mar 2025Grant (prize money)$124.4K
- Dec 2013Grant (prize money)$105.6K
#11
Series E · King Of Prussia, Pennsylvania · founded 2007 · 49 employees$251.3Mraised▾
Technology developer for cellulosic sugar. Its proprietary Plantrose Process pioneers the use of supercritical hydrolysis to break down non-food biomass quickly, using no significant consumables. The company produces cellulosic sugars from non-food based biomass, such as waste wood and agricultural residue. The resulting Plantro sugars serve as the intermediaries for partners to develop fossil fuel-based products.
- Mar 2020Series E$48.6M
- Sep 2016Series D$14M
- Jul 2016Series D$31.2M
- Mar 2015Series D$11.3M
#12
Series C · Devon, Pennsylvania · founded 1995 · 277 employees$75.5Mraised▾
Provider of used oil recycling company. Holds license for using patented UOP HyLube and HyLubeSAT technology through which used oil is recycled to produce base oils. Has partnered with Applied Graphene Materials to develop graphene-enhanced base oil formulation for machining and automotive applications. Operating 4-recycling facilities in the United States & Germany.
- Aug 2022Conventional Debt$15M
- Aug 2018Series C—
- Aug 2017Series C$75.5M
Funding & investor landscape
Notable founders
Market landscape — 10 sub-themes by coverage
Share of Sustainability Tech coverage by sub-theme.
Regulatory-risk over time rising
Funding & growth over time
funding rising · growth rising
How research on Climate Adaptation in Pennsylvania is moving
A read on the academic research around Climate Adaptation in Pennsylvania — which themes are gaining ground, the institutions and researchers driving them, and how the tone is shifting. Based on 44 papers.
Pennsylvania State University and peers lead flood risk, hydrology, and disaster resilience research across 44 papers, with concern-dominant framing (24 papers) and a near-neutral mean stance of 0.03.
- Pennsylvania State University30
- University of Pennsylvania8
- California University of Pennsylvania3
- Lincoln University - Pennsylvania2
- King\'s College - Pennsylvania1
- Flood myth2
- Flooding (psychology)1
- Natural disaster1
- Environmental resource management1
- Stakeholder1
- Flood myth1→6
- Climate change2→11
Common questions
Riya reads income statements for fun. She covers the real money in a sector — revenue, growth, who actually earns — and never met a vague claim she didn't want a number for.